发明授权
US07691632B2 Kit for detecting the level of cyclin-dependent kinase inhibitor P16 gene expression
失效
用于检测细胞周期蛋白依赖性激酶抑制剂P16基因表达水平的试剂盒
- 专利标题： Kit for detecting the level of cyclin-dependent kinase inhibitor P16 gene expression
- 专利标题（中）： 用于检测细胞周期蛋白依赖性激酶抑制剂P16基因表达水平的试剂盒
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申请号： US12195135申请日： 2008-08-20
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公开(公告)号： US07691632B2公开(公告)日： 2010-04-06
- 发明人: David H. Beach , Douglas J. Demetrick , Manuel Serrano , Gregory J. Hannon
- 申请人： David H. Beach , Douglas J. Demetrick , Manuel Serrano , Gregory J. Hannon
- 申请人地址： US NY Cold Spring Harbor
- 专利权人： Cold Spring Harbor Laboratory
- 当前专利权人： Cold Spring Harbor Laboratory
- 当前专利权人地址： US NY Cold Spring Harbor
- 代理机构： Howrey LLP
- 代理商 Viola T. Kung
- 主分类号： C07K16/00
- IPC分类号： C07K16/00
摘要：
The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a family of cell-cycle regulatory proteins (“CCR-proteins”). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15 kDa, each of which can function as an inhibitor of cell-cycle progression, and therefore ultimately of cell growth. The present invention comprises antibodies directed to such CCR-proteins. The present invention is directed to a kit for detecting the level of cyclin-dependent kinase inhibitor p16 gene expression comprising antibodies directed to a p16 protein.
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