发明授权
- 专利标题： Antibodies that bind TNF-α converting enzyme
- 专利标题（中）： 结合TNF-α转化酶的抗体
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申请号： US11709436申请日： 2007-02-21
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公开(公告)号： US07695948B2公开(公告)日： 2010-04-13
- 发明人: Roy A. Black , Charles Rauch , Carl J. March , Douglas P. Cerretti
- 申请人： Roy A. Black , Charles Rauch , Carl J. March , Douglas P. Cerretti
- 申请人地址： US CA Thousand Oaks
- 专利权人： Immunex Corporation
- 当前专利权人： Immunex Corporation
- 当前专利权人地址： US CA Thousand Oaks
- 代理商 Susan E. Lingenfelter
- 主分类号： C12N9/48
- IPC分类号： C12N9/48
摘要：
A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
公开/授权文献
- US20080160571A1 Antibodies that bind TNF-alpha converting enzyme 公开/授权日：2008-07-03
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