Invention Grant
US07695964B2 Compositions and methods for generating short double-stranded RNA using mutated RNAse III
失效
使用突变型RNA酶III产生短双链RNA的组合物和方法
- Patent Title: Compositions and methods for generating short double-stranded RNA using mutated RNAse III
- Patent Title (中): 使用突变型RNA酶III产生短双链RNA的组合物和方法
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Application No.: US10586720Application Date: 2005-01-21
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Publication No.: US07695964B2Publication Date: 2010-04-13
- Inventor: Claude V. Maina , George Tzertzinis , Sanjay Kumar
- Applicant: Claude V. Maina , George Tzertzinis , Sanjay Kumar
- Applicant Address: US MA Ipswich
- Assignee: New England Biolabs, Inc.
- Current Assignee: New England Biolabs, Inc.
- Current Assignee Address: US MA Ipswich
- Agent Harriet M. Strimpel; D. Phil
- International Application: PCT/US2005/002029 WO 20050121
- International Announcement: WO2005/072272 WO 20050811
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C12N5/02 ; G01N33/53
Abstract:
Compositions and methods are provided for preparing an hsiRNA mixture and for silencing of gene expression in vivo. The composition relates to a mutant RnaseIII. The methods are directed to reacting a preparation of dsRNA with an effective amount of a mutant RNAse III to produce the hsiRNA mixture.
Public/Granted literature
- US20070155684A1 Compositions and methods for generating short double-stranded rna using mutated rnase III Public/Granted day:2007-07-05
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