发明授权
- 专利标题： Protein kinase modulators and methods of use
- 专利标题（中）： 蛋白激酶调节剂和使用方法
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申请号： US10513081申请日： 2003-05-02
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公开(公告)号： US07704995B2公开(公告)日： 2010-04-27
- 发明人: Chris A. Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Wang Co , Sergey Epshteyn , Abigail R Kennedy , Baili Chen , Larisa Dubenko , Neel Kumar Anand , Tsze H. Tsang , John M. Nuss , Csaba J Peto , Kenneth D. Rice , Mohamed Abdulkader Ibrahim , Kevin Luke Schnepp , Xian Shi , James William Leahy , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Grace Mann , Larry Wayne Mann , Craig Stacy Takeuchi , Peter Lamb , David J. Matthews , Nicole Miller
- 申请人： Chris A. Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Wang Co , Sergey Epshteyn , Abigail R Kennedy , Baili Chen , Larisa Dubenko , Neel Kumar Anand , Tsze H. Tsang , John M. Nuss , Csaba J Peto , Kenneth D. Rice , Mohamed Abdulkader Ibrahim , Kevin Luke Schnepp , Xian Shi , James William Leahy , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Grace Mann , Larry Wayne Mann , Craig Stacy Takeuchi , Peter Lamb , David J. Matthews , Nicole Miller
- 申请人地址： US CA South San Francisco
- 专利权人： Exelixis, Inc.
- 当前专利权人： Exelixis, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP.
- 代理商 Robert L. Bernstein
- 国际申请： PCT/US03/13869 WO 20030502
- 国际公布： WO03/093297 WO 20031113
- 主分类号： C07D279/16
- IPC分类号： C07D279/16 ; C07D279/12 ; C07D417/12 ; C07D265/36 ; C07D413/12 ; C07D403/12 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D411/12 ; C07D419/12 ; C07D241/18 ; C07D241/20 ; A61K31/55 ; A61K31/497 ; A61K31/5355 ; A61K31/541 ; C07D305/12 ; C07D307/79 ; A61K31/44 ; A61P35/00
摘要：
This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.
公开/授权文献
- US20060211709A1 Protein kinase modulators and methods of use 公开/授权日：2006-09-21
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