Patent search ipc:"C07D279/16" Page 1

1.

发明申请
15-PGDH INHIBITOR 有权

公开(公告)号：US20230082516A1

公开(公告)日：2023-03-16

申请号：US17417201

申请日：2020-01-07

Applicant: KYORIN PHARMACEUTICAL CO., LTD.

Inventor： Shigeki SETO , Hitomi YAMADA , Yoshifumi SAITO , Haruaki KURASAKI

IPC: C07D265/36 , C07D267/02 , C07D267/22 , C07D498/04 , C07D281/02 , C07D519/00 , C07D279/16 , C07D471/04

Abstract: [Problem]
To provide a compound having a 15-PGDH inhibitory effect.
[Solution]
A compound represented by general formula (1) or a pharmacologically acceptable salt thereof.

2.

发明授权
Method for aromatic fluorination 有权

公开(公告)号：US11230517B2

公开(公告)日：2022-01-25

申请号：US17015775

申请日：2020-09-09

Applicant: DOW GLOBAL TECHNOLOGIES LLC , THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Melanie S. Sanford , Douglas Bland , Patrick S. Hanley , Megan A. Cismesia , Sydonie D. Schimler

IPC: C07C17/02 , C07D453/02 , C07D311/16 , C07C17/093 , C07D209/08 , C07D213/79 , C07D213/61 , C07C231/12 , C07C41/22 , C07C45/63 , C07D213/57 , C07C201/12 , C07C67/307 , C07D213/75 , C07J21/00 , C07D279/16 , C07C253/30 , C07D209/88 , C07D215/18 , C07C25/13 , C07C317/14

Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species.
Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species.
Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.

3.

发明申请
[6,6] FUSED BICYCLIC HDAC8 INHIBITORS 有权

公开(公告)号：US20210139439A1

公开(公告)日：2021-05-13

申请号：US17066385

申请日：2020-10-08

Applicant: Valo Early Discovery, Inc.

Inventor： Xiaozhang Zheng , Pui Yee Ng , Jennifer R. Thomason , Mary-Margaret Zablocki , Bingsong Han , Nicholas Barczak , Cuixian Liu , Aleksandra Rudnitskaya , David R. Lancia, JR. , Kenneth W. Bair

IPC: C07D265/36 , C07D413/12 , C07D413/06 , C07D401/04 , C07D279/16 , C07D491/107 , C07D413/10 , C07D471/04 , C07D417/06 , C07D513/04 , C07D487/04 , C07D265/34 , C07D279/14

Abstract: The present invention is directed to compounds of Formula I: and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or isomers or thereof, wherein R1, R2, R2′, L, X, W, Y1, Y2, Y3, and Y4 are described herein.

4.

发明申请
SUBSTITUTED BENZOXAZINE AND RELATED COMPOUNDS 审中-公开

公开(公告)号：US20190106394A1

公开(公告)日：2019-04-11

申请号：US16104840

申请日：2018-08-17

Applicant: THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID

Inventor： Andrey S. Tsvetkov , Steven M. Finkbeiner , Michael A. Pleiss , Robert Greenhouse

IPC: C07D265/36 , C07D498/04 , A61K9/08 , A61K9/10 , C07D279/28 , C07D279/16 , C07D209/08 , A61K9/02 , C07D413/06 , A61K9/48 , A61K9/20

Abstract: The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.

5.

发明授权
Substituted benzoxazine and related compounds 有权

公开(公告)号：US10087151B2

公开(公告)日：2018-10-02

申请号：US15110082

申请日：2015-01-08

Applicant: THE J. DAVID GLADSTONE INSTITUTES, A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE

Inventor： Andrey S. Tsvetkov , Steven M. Finkbeiner , Michael A. Pleiss , Robert Greenhouse

IPC: C07D265/36 , C07D413/06 , C07D498/04 , C07D209/08 , C07D279/16 , C07D279/28 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/20 , A61K9/48

Abstract: The present invention relates to compounds including but not limited to of any one of formulas Ia, Ib, IIa, IIb, IIIa, IIIb, and IV to VI, VIIa, VIIb, VIIIa, VIIIb and VIIIc as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.

6.

发明授权
Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease 有权

公开(公告)号：US09896441B2

公开(公告)日：2018-02-20

申请号：US15308736

申请日：2015-05-05

Applicant: Lycera Corporation

Inventor： Thomas D. Aicher , Clarke B. Taylor , Chad A. VanHuis

IPC: C07D413/12 , C07D413/06 , C07D265/36 , C07D215/58 , C07D491/10 , C07D417/12 , C07D401/12 , C07D413/14 , C07D498/08 , C07D471/04 , C07D513/04 , C07D417/06 , C07D417/14 , C07D401/06 , C07D487/04 , C07D311/22 , C07D279/16

CPC classification number: C07D413/12 , C07D215/58 , C07D265/36 , C07D279/16 , C07D311/22 , C07D401/06 , C07D401/12 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D498/08 , C07D513/04

Abstract: The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORγ activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

7.

发明授权
Estrogen receptor modulators and uses thereof 有权
Title translation: 雌激素受体调节剂及其用途

公开(公告)号：US09399646B2

公开(公告)日：2016-07-26

申请号：US13821190

申请日：2011-09-15

Applicant: Nicholas D. Smith , Mehmet Kahraman , Steven P. Govek , Johnny Y. Nagasawa , Andiliy G. Lai , Jackaline D. Julien , Mark R. Herbert , Celine Bonnefous , Karensa L. Douglas

Inventor： Nicholas D. Smith , Mehmet Kahraman , Steven P. Govek , Johnny Y. Nagasawa , Andiliy G. Lai , Jackaline D. Julien , Mark R. Herbert , Celine Bonnefous , Karensa L. Douglas

IPC: C07D495/04 , C07D209/08 , C07D231/56 , C07D249/18 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , C07D215/227 , C07D217/24 , C07D265/18 , C07D277/68 , C07D279/16 , C07D401/10 , C07D409/10 , C07D471/04 , C07D401/12 , C07D403/10 , C07D413/10 , C07D417/10

CPC classification number: C07D231/56 , A61K31/416 , A61K31/7056 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K31/7105 , C07C215/10 , C07D209/08 , C07D215/227 , C07D217/24 , C07D249/18 , C07D265/18 , C07D277/68 , C07D279/16 , C07D401/10 , C07D401/12 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07D495/04

Abstract: Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

Abstract translation: 本文描述的是雌激素受体调节剂的化合物。还描述了包括本文所述化合物的药物组合物和药物，以及使用这种雌激素受体调节剂单独和与其它化合物组合用于治疗介导或依赖于雌激素受体的疾病或病症的方法。

8.

发明授权
Multifunctional radical quenchers for the treatment of mitochondrial dysfunction 有权
Title translation: 多功能自由基猝灭剂治疗线粒体功能障碍

公开(公告)号：US09334250B2

公开(公告)日：2016-05-10

申请号：US14432885

申请日：2013-10-02

Applicant: Sandipan Roy Chowdhury , Omar Khdour , Sidney Hecht

Inventor： Sandipan Roy Chowdhury , Omar Khdour , Sidney Hecht

IPC: C07D279/16

CPC classification number: C07D279/16

Abstract: The present disclosure provides compounds of formula (I): compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Abstract translation: 本公开内容提供了式（I）化合物：包含这些化合物的组合物，以及在各种应用中使用这些化合物的方法，例如治疗或抑制与线粒体功能降低相关的疾病，导致ATP产生和/或氧化应激减少和/或脂质过氧化。

9.

发明授权
Process for producing optically active amine 有权
Title translation: 光学活性胺的制备方法

公开(公告)号：US09328079B2

公开(公告)日：2016-05-03

申请号：US14421481

申请日：2013-09-06

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Takeshi Ohkuma , Noriyoshi Arai , Kazuhiko Matsumura

IPC: C07D279/16 , C07D241/42 , C07D265/36 , C07B53/00

CPC classification number: C07D279/16 , C07B53/00 , C07D241/42 , C07D265/36

Abstract: A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein P represents an optically active diphosphine, X represents an anionic group, and Ar represents an optionally substituted arylene group).

Abstract translation: 一种制备光学活性胺化合物的方法，其特征在于在通式（1）或（2）表示的钌络合物存在下不对称氢化前手性碳 - 氮双键（其中P表示光学活性二膦，X表示阴离子基团，Ar表示可以具有取代基的亚芳基）。