发明授权
- 专利标题: Thermogelling polymer blends for biomaterial applications
- 专利标题(中): 用于生物材料应用的热凝胶聚合物共混物
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申请号: US10837082申请日: 2004-04-30
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公开(公告)号: US07708979B2公开(公告)日: 2010-05-04
- 发明人: Anthony M. Lowman , Michele S. Marcolongo , Alastair J. T. Clemow
- 申请人: Anthony M. Lowman , Michele S. Marcolongo , Alastair J. T. Clemow
- 申请人地址: US PA West Chester US PA Philadelphia
- 专利权人: Synthes USA, LLC,Drexel University
- 当前专利权人: Synthes USA, LLC,Drexel University
- 当前专利权人地址: US PA West Chester US PA Philadelphia
- 代理机构: Stroock & Stroock & Lavan LLP
- 主分类号: A61K49/04
- IPC分类号: A61K49/04 ; A61F13/00 ; A61F2/00 ; A61K31/74 ; A61M31/00
摘要:
Thermogelling polymers are described containing poly (n-isopropyl acrylamide). Solutions of this polymer, copolymers or mixtures of the polymer with a second polymer such as poly(ethylene glycol), poly (vinyl pyrrolidone) or poly(vinyl alcohol) are liquids at room temperature and solids at body temperature. Thus, also provided are methods of implanting a hydrogel into a mammal by injecting the solution as a liquid at a temperature below body temperature into a selected site in the mammal at a temperature below body temperature, which then undergoes thermal phase transition to form a solid hydrogel in situ in the body as the implant warms to body temperature. Methods for using these thermal gelling materials in various applications including nucleus pulposus replacement/augmentation, wound care, disk replacement, cartilage replacement, joint replacement, surgical barriers, gastrointestinal devices, cosmetic and reconstructive surgery, and breast enlargement are also provided.