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    Hydrogel compositions and manufacturing process for ultrasound couplants
    3.
    发明授权
    Hydrogel compositions and manufacturing process for ultrasound couplants 失效
    水凝胶组合物和超声耦合剂的制造工艺

    公开(公告)号：US07736619B2

    公开(公告)日：2010-06-15

    申请号：US10978767

    申请日：2004-11-01

    申请人： Anthony M. Lowman ,  Larry L. Smith

    发明人： Anthony M. Lowman ,  Larry L. Smith

    IPC分类号： A61B8/00 ,  A61K49/00

    CPC分类号： C08L29/04 ,  A61B8/4281 ,  C08L39/06 ,  C08L71/02 ,  C08L2205/03 ,  G10K11/02 ,  C08L2666/04 ,  C08L2666/14 ,  C08L2666/02

    摘要： A hydrogel coupling device for the transmission of ultrasound therethrough having a predetermined shape and comprising a hydrogen bonded composition comprising PVA, one or both of PVP and PEG, and the balance water. The predetermined shapes are formed and are then exposed to (a) one or more freeze/thaw cycles, (b) one or more dehydration/re-hydration cycles, or (c) one or more freeze/thaw cycles and one or more dehydration/re-hydration cycles. The shapes may further be irradiated with high energy radiation followed by heat treating.

    摘要翻译： 一种用于透射超声波的水凝胶耦合装置，其具有预定形状，并且包括含有PVA，PVP和PEG中的一种或两者以及余量的水的氢键合组合物。 形成预定形状，然后暴露于（a）一个或多个冻融循环，（b）一个或多个脱水/再水合循环，或（c）一个或多个冻融循环和一次或多次脱水 /再水合循环。 可以用高能量辐射进一步照射形状，然后进行热处理。

    HYDROGEL BALLOON PROSTHESIS FOR NUCLEUS PULPOSUS
    4.
    发明申请
    HYDROGEL BALLOON PROSTHESIS FOR NUCLEUS PULPOSUS 审中-公开
    氢化球藻对核仁的影响

    公开(公告)号：US20100047437A1

    公开(公告)日：2010-02-25

    申请号：US12608565

    申请日：2009-10-29

    申请人： Edward Vresilovic ,  Michele S. Marcolongo ,  Anthony M. Lowman ,  Alastair J. T. Clemow ,  Michael F. Keane

    发明人： Edward Vresilovic ,  Michele S. Marcolongo ,  Anthony M. Lowman ,  Alastair J. T. Clemow ,  Michael F. Keane

    IPC分类号： A61L33/04

    CPC分类号： A61L27/52 ,  A61F2/30767 ,  A61F2/441 ,  A61F2002/444

    摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.

    摘要翻译： 用于替换或补充椎间盘髓核的假体是具有柔性壁的可扩张容器，该容器适于通过狭窄的插管插入到椎间盘的中心空腔中，并且柔性壁由生物相容性 水凝胶。 优选的水凝胶是由聚（乙烯醇）和聚（乙烯基吡咯烷酮）的水溶液形成的冷冻凝胶。 假体可以通过用形成水凝胶的聚合物或这种聚合物的混合物的水溶液浸渍心轴来制备，通过冷却使涂覆的溶液凝胶化，并使凝胶涂层进行一系列重复的冻融处理。 在使用中，将假体插入到椎间盘的中心空腔中，并填充有生物相容性材料，例如生物相容性液体，生物相容性聚合物和生物相容性水凝胶，特别是热胶凝水凝胶。

    Bioadhesive hydrogels
    6.
    发明授权
    Bioadhesive hydrogels 有权
    生物粘合剂水凝胶

    公开(公告)号：US08366778B2

    公开(公告)日：2013-02-05

    申请号：US12812141

    申请日：2009-01-12

    申请人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell

    发明人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell

    IPC分类号： A61F2/44

    CPC分类号： A61L24/043 ,  A61L2430/38

    摘要： A method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second component and a third component, wherein the first component, the second component and the third component are crosslinked. The first component comprises an amine-containing polymer component at a concentration from about 0.1% weight by weight to about 13.65% weight by weight. The second component comprises a hydrophilic polymer or pre-polymer component at a concentration from about 3% weight by weight to about 35% weight by weight. The third component comprises an aldehyde component at a concentration from about 0.1% weight by weight to about 30% weight by weight. A method of repairing or supplementing a nucleus pulposus of an intervertebral disc comprises implanting the bioadhesive hydrogel composition in a patient.

    摘要翻译： 一种形成方法和所得到的用于修复或补充椎间盘髓核的生物粘附性水凝胶组合物包括至少第一组分，第二组分和第三组分，其中第一组分，第二组分和第三组分是交联的 。 第一组分包含浓度为约0.1重量％至约13.65重量％的含胺聚合物组分。 第二组分包含浓度为约3重量％至约35重量％的亲水性聚合物或预聚物组分。 第三组分包含浓度为约0.1重量％至约30重量％的醛组分。 修复或补充椎间盘的髓核的方法包括将生物粘附性水凝胶组合物植入患者体内。

    Hydrogel balloon prosthesis for nucleus pulposus
    7.
    发明授权
    Hydrogel balloon prosthesis for nucleus pulposus 有权
    水髓球囊假体为髓核

    公开(公告)号：US08287595B2

    公开(公告)日：2012-10-16

    申请号：US11510747

    申请日：2006-08-25

    申请人： Edward Vresilovic ,  Michele S. Marcolongo ,  Anthony M. Lowman ,  Alastair J. T. Clemow ,  Michael F. Keane

    发明人： Edward Vresilovic ,  Michele S. Marcolongo ,  Anthony M. Lowman ,  Alastair J. T. Clemow ,  Michael F. Keane

    IPC分类号： A61F2/44

    CPC分类号： A61L27/52 ,  A61F2/30767 ,  A61F2/441 ,  A61F2002/444

    摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.

    摘要翻译： 用于替换或补充椎间盘髓核的假体是具有柔性壁的可扩张容器，该容器适于通过狭窄的插管插入到椎间盘的中心空腔中，并且柔性壁由生物相容性 水凝胶。 优选的水凝胶是由聚（乙烯醇）和聚（乙烯基吡咯烷酮）的水溶液形成的冷冻凝胶。 假体可以通过用形成水凝胶的聚合物或这种聚合物的混合物的水溶液浸渍心轴来制备，通过冷却使涂覆的溶液凝胶化，并使凝胶涂层进行一系列重复的冻融处理。 在使用中，将假体插入到椎间盘的中心空腔中，并填充有生物相容性材料，例如生物相容性液体，生物相容性聚合物和生物相容性水凝胶，特别是热胶凝水凝胶。