发明授权
- 专利标题： Influenza A virus vaccines and inhibitors
- 专利标题（中）： 甲型流感病毒疫苗和抑制剂
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申请号： US11566216申请日： 2006-12-02
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公开(公告)号： US07709190B2公开(公告)日： 2010-05-04
- 发明人: Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
- 申请人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
- 申请人地址： US TX Austin
- 专利权人： Board of Regents, The University of Texas System
- 当前专利权人： Board of Regents, The University of Texas System
- 当前专利权人地址： US TX Austin
- 代理机构： Chalker Flores, LLP
- 代理商 Edwin S. Flores; Chainey P. Singleton
- 主分类号： C12Q1/70
- IPC分类号： C12Q1/70
摘要：
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
公开/授权文献
- US20080108050A1 INFLUENZA A VIRUS VACCINES AND INHIBITORS 公开/授权日：2008-05-08
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