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公开(公告)号：US07709190B2
公开(公告)日：2010-05-04
申请号：US11566216
申请日：2006-12-02
申请人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
发明人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61B50/39 , A61K38/162 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07K14/47 , C12N7/00 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
摘要翻译： 本发明包括与流感A非结构蛋白1（NS1）表面上的细胞多聚腺苷酸化和特异性因子30（CPSF30）结合位点的结构和功能有关的组合物和方法。 具体来说，描述了关键的生物化学试剂，结晶和NMR分析条件，测定和一般方法，用于（i）发现，设计和优化甲型流感（A型）禽流感病毒的小分子抑制剂和（ii）产生减毒流感病毒株 适合禽类和人类流感疫苗的开发。
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公开(公告)号：US08455621B2
公开(公告)日：2013-06-04
申请号：US12706804
申请日：2010-02-17
申请人： Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo , Gaetano Montelione , Edward Arnold , Kalyan Das , LiChung Ma , Rong Xiao
发明人： Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo , Gaetano Montelione , Edward Arnold , Kalyan Das , LiChung Ma , Rong Xiao
IPC分类号： C07K1/00
CPC分类号： C07K14/005 , A61B50/39 , A61K38/162 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07K14/47 , C12N7/00 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
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公开(公告)号：US20080108050A1
公开(公告)日：2008-05-08
申请号：US11566216
申请日：2006-12-02
申请人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
发明人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
CPC分类号： C07K14/005 , A61B50/39 , A61K38/162 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07K14/47 , C12N7/00 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
摘要翻译： 本发明包括与流感A非结构蛋白1（NS1）表面上的细胞多聚腺苷酸化和特异性因子30（CPSF30）结合位点的结构和功能有关的组合物和方法。 具体来说，描述了关键的生物化学试剂，结晶和NMR分析条件，测定和一般方法，用于（i）发现，设计和优化甲型流感（A型）禽流感病毒的小分子抑制剂和（ii）产生减毒流感病毒株 适合禽类和人类流感疫苗的开发。
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公开(公告)号：US20100247569A1
公开(公告)日：2010-09-30
申请号：US12706804
申请日：2010-02-17
申请人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
发明人： Gaetano Montelione , Kalyan Das , Edward Arnold , LiChung Ma , Rong Xiao , Robert M. Krug , Karen Y. Twu , Rei-Lin Kuo
IPC分类号： A61K39/145 , C12N7/04 , A61P31/16 , C07K14/00
CPC分类号： C07K14/005 , A61B50/39 , A61K38/162 , A61K39/145 , A61K2039/5254 , A61K2039/53 , C07K14/47 , C12N7/00 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162
摘要： The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
摘要翻译： 本发明包括与流感A非结构蛋白1（NS1）表面上的细胞多聚腺苷酸化和特异性因子30（CPSF30）结合位点的结构和功能有关的组合物和方法。 具体来说，描述了关键的生物化学试剂，结晶和NMR分析条件，测定和一般方法，用于（i）发现，设计和优化甲型流感（A型）禽流感病毒的小分子抑制剂和（ii）产生减毒流感病毒株 适合禽类和人类流感疫苗的开发。
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5.发明申请Linking gene sequence to gene function by three dimensional (3D) protein structure determination 审中-公开通过三维（3D）蛋白质结构测定将基因序列与基因功能连接公开(公告)号：US20050233357A1
公开(公告)日：2005-10-20
申请号：US11067337
申请日：2005-02-25
IPC分类号： G01N33/68 , G06F19/16 , G06F19/18 , G06F19/24 , G06F19/28 , C12Q1/68 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G01N33/6803 , G16B15/00 , G16B20/00 , G16B40/00 , G16B50/00
摘要： The present invention provides a structure-functional analysis engine for the high-throughput determination of the biochemical function of proteins or protein domains of unknown function. The present invention uses bioinformatics, molecular biology and nuclear magnetic resonance tools for the rapid and automated determination of the three-dimensional structures of proteins and protein domains.
摘要翻译： 本发明提供了用于高通量测定未知功能的蛋白质或蛋白质结构域的生化功能的结构功能分析引擎。 本发明使用生物信息学，分子生物学和核磁共振工具快速和自动测定蛋白质和蛋白质结构域的三维结构。
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