Invention Grant
- Patent Title: Marker for prenatal diagnosis and monitoring
- Patent Title (中): 产前诊断和监测的标记
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Application No.: US11144951Application Date: 2005-06-03
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Publication No.: US07709194B2Publication Date: 2010-05-04
- Inventor: Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Yu-kwan Tong , Chunming Ding
- Applicant: Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Yu-kwan Tong , Chunming Ding
- Applicant Address: CN Shatin, New Territories, Hong Kong
- Assignee: The Chinese University of Hong Kong
- Current Assignee: The Chinese University of Hong Kong
- Current Assignee Address: CN Shatin, New Territories, Hong Kong
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12Q1/68
Abstract:
The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
Public/Granted literature
- US20060019278A1 Marker for prenatal diagnosis and monitoring Public/Granted day:2006-01-26
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