Invention Grant
US07709481B2 Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and methods for their use as pharmaceuticals
有权
苯基-1,2,4-恶二唑酮衍生物，其制备方法及其用作药物的方法
- Patent Title: Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and methods for their use as pharmaceuticals
- Patent Title (中): 苯基-1,2,4-恶二唑酮衍生物，其制备方法及其用作药物的方法
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Application No.: US12055780Application Date: 2008-03-26
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Publication No.: US07709481B2Publication Date: 2010-05-04
- Inventor: Stefanie Keil , Matthias Urmann , Patrick Bernardelli , Maike Glien , Wolfgang Wendler , Karen Chandross , Lan Lee
- Applicant: Stefanie Keil , Matthias Urmann , Patrick Bernardelli , Maike Glien , Wolfgang Wendler , Karen Chandross , Lan Lee
- Applicant Address: FR Paris
- Assignee: Sanofi-Aventis
- Current Assignee: Sanofi-Aventis
- Current Assignee Address: FR Paris
- Agent Jiang Lin
- Priority: EP05021277 20050929
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/4245 ; A61P3/00 ; C07D413/12 ; C07D413/14
Abstract:
The inventive compounds of the present invention are comprised of phenyl and pyridinyl-1,2,4-oxadiazolone derivatives and their physiologically acceptable salts and functional derivatives that are shown to provide peroxisome proliferator activator receptor (PPARdelta) agonist activity. The compounds of the present invention are comprised of the formula: wherein the substituents R1-R5 and R7-R10 are defined herein. The compounds are therapeutically effective in the regulation and modulation of lipid and carbohydrate metabolism in mammals and are thus suitable for the treatment of diseases such as type-2 diabetes, atherosclerosis, cardiovascular disorders and the like.
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