发明授权
- 专利标题： Polynucleotides encoding anti-ganglioside antibodies
- 专利标题（中）： 编码抗神经节苷脂抗体的多核苷酸
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申请号： US10564665申请日： 2004-07-15
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公开(公告)号： US07709615B2公开(公告)日： 2010-05-04
- 发明人: Reiko Irie , Hiroyuki Tsunoda , Tomoyuki Igawa , Yasuo Sekimori , Masayuki Tsuchiya
- 申请人： Reiko Irie , Hiroyuki Tsunoda , Tomoyuki Igawa , Yasuo Sekimori , Masayuki Tsuchiya
- 申请人地址： JP Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 代理机构： Fish & Richardson P.C.
- 国际申请： PCT/JP2004/010444 WO 20040715
- 国际公布： WO2005/005636 WO 20050120
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
IgM can be obtained in the form of a pentamer by placing the genes encoding the H, L, and J chains on the same vector to transform appropriate host cells. The gene encoding the J chain may be introduced by co-transfection. When no J chain is expressed, the IgM is produced as a hexamer. The transformants obtained according to the present invention achieve a high yield of IgM. The present invention also provides methods which enable separation and quantification of polymeric IgM.
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