发明授权
US07709646B2 Tetrahydroquinoline derivatives useful as serine protease inhibitors
有权
用作丝氨酸蛋白酶抑制剂的四氢喹啉衍生物
- 专利标题： Tetrahydroquinoline derivatives useful as serine protease inhibitors
- 专利标题（中）： 用作丝氨酸蛋白酶抑制剂的四氢喹啉衍生物
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申请号： US11430588申请日： 2006-05-09
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公开(公告)号： US07709646B2公开(公告)日： 2010-05-04
- 发明人: Mimi L. Quan , Cailan Wang , Jinglan Zhou , Jon J. Hangeland , Dietmar A. Seiffert , Robert M. Knabb
- 申请人： Mimi L. Quan , Cailan Wang , Jinglan Zhou , Jon J. Hangeland , Dietmar A. Seiffert , Robert M. Knabb
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Jing G. Sun
- 主分类号： C07D215/38
- IPC分类号： C07D215/38
摘要：
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4, R4, R5, R13, R14, R15 and R16 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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