A control device of an internal combustion engine includes: a target negative pressure setting section that set a target negative intake pipe pressure during cold acceleration to a negative intake pipe pressure larger than a negative intake pipe pressure prior to the cold acceleration; a throttle valve control section that controls a throttle valve so that the negative intake pipe pressure increases during cold acceleration; and an intake valve control section that controls a variable valve mechanism of an intake valve, based on the target negative intake pipe pressure, to obtain a target intake air amount.