Embodiments of the present invention provide a method, apparatus, and system of wireless transmission with frame alignment. For example, a method in accordance with demonstrative embodiments of the invention may include synchronizing between a transmitter using a first modulation scheme, which may have multiple frame formats, and a receiver using a second modulation scheme, by calculating a transmission time that aligns an inter frame space start time of the first and second modulation schemes. Other features are described and claimed.