发明授权
- 专利标题： Methods for producing members of specific binding pairs
- 专利标题（中）： 生产特异性结合对成员的方法
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申请号： US10803622申请日： 2004-03-18
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公开(公告)号： US07732377B2公开(公告)日： 2010-06-08
- 发明人: John McCafferty , Anthony Richard Pope , Kevin Stuart Johnson , Henricus Renerus Jacobus Mattheus Hoogenboom , Andrew David Griffiths , Ronald Henry Jackson , Kaspar Philipp Holliger , James David Marks , Timothy Piers Clackson , David John Chiswell , Gregory Paul Winter , Timothy Peter Bonnert
- 申请人： John McCafferty , Anthony Richard Pope , Kevin Stuart Johnson , Henricus Renerus Jacobus Mattheus Hoogenboom , Andrew David Griffiths , Ronald Henry Jackson , Kaspar Philipp Holliger , James David Marks , Timothy Piers Clackson , David John Chiswell , Gregory Paul Winter , Timothy Peter Bonnert
- 申请人地址： GB Cambridgeshire GB Cambridge
- 专利权人： Medical Research Council,MedImmune Limited
- 当前专利权人： Medical Research Council,MedImmune Limited
- 当前专利权人地址： GB Cambridgeshire GB Cambridge
- 代理机构： Howrey LLP
- 主分类号： C40B30/04
- IPC分类号： C40B30/04 ; C12Q1/70 ; G01N33/53
摘要：
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a filamentous bacteriophage particle containing DNA encoding the sbp member, wherein the sbp member has a binding domain that consists of a dAb fragment. The displayed sbps may be selected by affinity with a complementary sbp member, and the DNA recovered from selected filamentous bacteriophage particles for expression of the selected sbp members.
公开/授权文献
- US20040157214A1 Methods for producing members of specific binding pairs 公开/授权日：2004-08-12
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