发明授权
- 专利标题: Surgical device for skin therapy or testing
- 专利标题(中): 用于皮肤治疗或测试的手术装置
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申请号: US10092237申请日: 2002-03-06
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公开(公告)号: US07741116B2公开(公告)日: 2010-06-22
- 发明人: Steven T. Boyce
- 申请人: Steven T. Boyce
- 申请人地址: US OH Cincinnati US FL Tampa
- 专利权人: University of Cincinnati,Shriners Hospitals For Childrens
- 当前专利权人: University of Cincinnati,Shriners Hospitals For Childrens
- 当前专利权人地址: US OH Cincinnati US FL Tampa
- 代理机构: Thompson Hine LLP
- 主分类号: C12N5/06
- IPC分类号: C12N5/06 ; C12N5/02 ; C12N5/08
摘要:
A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels. The inventive device is easy to handle and manipulate for surgical transplant, can be made into large sheets to minimize the number of grafts required to cover a large surface area to be treated, and can be produced within the time frame to treat a burned individual requiring a skin graft.
公开/授权文献
- US20030170892A1 Surgical device for skin therapy or testing 公开/授权日:2003-09-11