发明授权
US07745476B2 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
有权
具有CB1拮抗活性的1,3,5-三取代的4,5-二氢-1H-吡唑衍生物
- 专利标题： 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
- 专利标题（中）： 具有CB1拮抗活性的1,3,5-三取代的4,5-二氢-1H-吡唑衍生物
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申请号： US11033683申请日： 2005-01-13
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公开(公告)号： US07745476B2公开(公告)日： 2010-06-29
- 发明人: Josephus H. M. Lange , Cornelis G. Kruse , Herman H. Van Stuivenberg
- 申请人： Josephus H. M. Lange , Cornelis G. Kruse , Herman H. Van Stuivenberg
- 申请人地址： NL Weesp
- 专利权人： Solvay Pharmaceuticals B.V.
- 当前专利权人： Solvay Pharmaceuticals B.V.
- 当前专利权人地址： NL Weesp
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; C07D231/06
摘要：
The present invention relates to 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives as CB1 antagonists, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said pyrazole derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect.The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.
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