发明授权
- 专利标题: Electrical stimulation combined with a biologic to increase osteogenesis
- 专利标题(中): 电刺激结合生物增加成骨
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申请号: US10383251申请日: 2003-03-07
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公开(公告)号: US07747332B2公开(公告)日: 2010-06-29
- 发明人: Michael B. McGraw , William A. Rux , William J. Carroll , Richard M. Terrell , Randy Alan Murphy
- 申请人: Michael B. McGraw , William A. Rux , William J. Carroll , Richard M. Terrell , Randy Alan Murphy
- 专利权人: International Rehabilitative Sciences, Inc.
- 当前专利权人: International Rehabilitative Sciences, Inc.
- 代理机构: Blank Rome LLP
- 主分类号: A61N1/00
- IPC分类号: A61N1/00
摘要:
An electrical stimulation device is combined with a biologic to increase osteogenesis (i.e., bone healing or bone formation). The electrical stimulation is osteoblastic in that it produces new bone cells and or increases the activity of the existing cells, either osteoblasts or osteocytes. The preferred biologic decreases osteoclastic activity, which is the remodeling of bone usually by destroying the bone. Thus, osteogenesis is maximized by decreasing osteoclastic activity, while at the same time increasing osteoblastic activity. Osteogenesis can also be maximized by combining electrical stimulation with a BMP. Though BMPs are generally considered to increase osteoblastic activity, certain BMPs may have an additive effect to the use of electrical stimulation.
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