发明授权
US07747395B2 Method of inhibitor design and identification using a 3-D structure of human peptide deformylase
有权
使用人肽脱甲酰酶的3-D结构的抑制剂设计和鉴定方法
- 专利标题： Method of inhibitor design and identification using a 3-D structure of human peptide deformylase
- 专利标题（中）： 使用人肽脱甲酰酶的3-D结构的抑制剂设计和鉴定方法
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申请号： US11787237申请日： 2007-04-13
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公开(公告)号： US07747395B2公开(公告)日： 2010-06-29
- 发明人: David A. Scheinberg , Sindy Noemi Escobar-Alvarez , Yehuda Goldgur , Yueming Li
- 申请人： David A. Scheinberg , Sindy Noemi Escobar-Alvarez , Yehuda Goldgur , Yueming Li
- 申请人地址： US NY New York
- 专利权人： Sloan-Kettering Institute for Cancer Research
- 当前专利权人： Sloan-Kettering Institute for Cancer Research
- 当前专利权人地址： US NY New York
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 代理商 C. Hunter Baker
- 主分类号： G01N31/00
- IPC分类号： G01N31/00 ; C12Q1/34 ; C12Q1/00
摘要：
The present invention provides the three-dimensional structure of human mitochondrial Homo sapiens peptide deformylase (HsPDF) protein, and HsPDF complexed to a binding compound, such as a PDF inhibitor. This crystallographic information will aid in the identification and development of novel binding compounds of HsPDF and other PDF family members which have anti-bacterial, anti-viral, anti-parasitical, anti-inflammatory, and/or anti-cancer activity.
公开/授权文献
- US20080254442A1 Crystal structures of human peptide deformylase 公开/授权日：2008-10-16
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