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公开(公告)号：US20080254442A1
公开(公告)日：2008-10-16
申请号：US11787237
申请日：2007-04-13
CPC分类号： C12N9/78 , C07K2299/00 , C07K2319/21 , C12Y305/01088 , G01N2333/978 , G01N2500/04 , G01N2500/20
摘要： The present invention provides the three-dimensional structure of human mitochondrial Homo sapiens peptide deformylase (HsPDF) protein, and HsPDF complexed to a binding compound, such as a PDF inhibitor. This crystallographic information will aid in the identification and development of novel binding compounds of HsPDF and other PDF family members which have anti-bacterial, anti-viral, anti-parasitical, anti-inflammatory, and/or anti-cancer activity.
摘要翻译： 本发明提供人类线粒体智人肽脱甲酰酶（HsPDF）蛋白质的三维结构和与结合化合物如PDF抑制剂复合的HsPDF。 这种晶体学信息将有助于鉴定和开发具有抗细菌，抗病毒，抗寄生，抗炎和/或抗癌活性的HsPDF和其他PDF家族成员的新型结合化合物。
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2.发明授权Method of inhibitor design and identification using a 3-D structure of human peptide deformylase 有权使用人肽脱甲酰酶的3-D结构的抑制剂设计和鉴定方法公开(公告)号：US07747395B2
公开(公告)日：2010-06-29
申请号：US11787237
申请日：2007-04-13
CPC分类号： C12N9/78 , C07K2299/00 , C07K2319/21 , C12Y305/01088 , G01N2333/978 , G01N2500/04 , G01N2500/20
摘要： The present invention provides the three-dimensional structure of human mitochondrial Homo sapiens peptide deformylase (HsPDF) protein, and HsPDF complexed to a binding compound, such as a PDF inhibitor. This crystallographic information will aid in the identification and development of novel binding compounds of HsPDF and other PDF family members which have anti-bacterial, anti-viral, anti-parasitical, anti-inflammatory, and/or anti-cancer activity.
摘要翻译： 本发明提供人类线粒体智人肽脱甲酰酶（HsPDF）蛋白质的三维结构和与结合化合物如PDF抑制剂复合的HsPDF。 这种晶体学信息将有助于鉴定和开发具有抗细菌，抗病毒，抗寄生，抗炎和/或抗癌活性的HsPDF和其他PDF家族成员的新型结合化合物。
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