发明授权
- 专利标题： Diazabicyclic aryl derivatives and their medical use
- 专利标题（中）： 二氮杂双环芳基衍生物及其医疗用途
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申请号： US11884345申请日： 2006-02-13
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公开(公告)号： US07750011B2公开(公告)日： 2010-07-06
- 发明人: Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring
- 申请人： Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring
- 申请人地址： DK Ballerup
- 专利权人： Neurosearch A/S
- 当前专利权人： Neurosearch A/S
- 当前专利权人地址： DK Ballerup
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： DK200500229 20050215
- 国际申请： PCT/EP2006/050873 WO 20060213
- 国际公布： WO2006/087305 WO 20060824
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D401/04 ; C07D409/04 ; C07D405/14 ; A61K31/501 ; A61K31/497 ; A61P21/00 ; A61P5/00 ; A61P25/00 ; A61P29/00
摘要：
This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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