Diazabicyclic aryl derivatives as cholinergic receptor modulators
    5.
    发明授权
    Diazabicyclic aryl derivatives as cholinergic receptor modulators 失效
    二氮杂双环芳基衍生物作为胆碱能受体调节剂

    公开(公告)号:US08236793B2

    公开(公告)日:2012-08-07

    申请号:US12633505

    申请日:2009-12-08

    IPC分类号: A61K31/55 C07D243/10

    CPC分类号: C07D471/08

    摘要: This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译: 本发明涉及新的二氮杂双环芳基衍生物,其在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体。 由于其药理学特征,本发明的化合物可用于治疗与中枢神经系统(CNS),周围神经系统(PNS),疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩,内分泌疾病或病症,与神经变性相关的疾病或病症,与由化学物质的滥用终止引起的炎症,疼痛和戒断症状相关的疾病或病症。