Invention Grant
US07754213B2 High affinity antibody antagonists of interleukin-13 receptor alpha 1
有权
白细胞介素-13受体α1的高亲和力抗体拮抗剂
- Patent Title: High affinity antibody antagonists of interleukin-13 receptor alpha 1
- Patent Title (中): 白细胞介素-13受体α1的高亲和力抗体拮抗剂
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Application No.: US11875017Application Date: 2007-10-19
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Publication No.: US07754213B2Publication Date: 2010-07-13
- Inventor: Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
- Applicant: Andrew Donald Nash , Manuel Baca , Louis Jerry Fabri , Dennis Zaller , William R. Strohl , Zhiqiang An
- Applicant Address: US NJ Rahway AU Parkville, Victoria
- Assignee: Merck & Co., Inc.,CSL Limited
- Current Assignee: Merck & Co., Inc.,CSL Limited
- Current Assignee Address: US NJ Rahway AU Parkville, Victoria
- Agency: Licata & Tyrrell P.C.
- Main IPC: A61K39/395
- IPC: A61K39/395

Abstract:
High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.
Public/Granted literature
- US20080166343A1 High affinity antibody antagonists of interleukin-13 receptor alpha 1 Public/Granted day:2008-07-10
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