公开(公告)号：US08420093B2

公开(公告)日：2013-04-16

申请号：US13361143

申请日：2012-01-30

申请人： Gene Kinney ,  William R. Strohl ,  Zhiqiang An

发明人： Gene Kinney ,  William R. Strohl ,  Zhiqiang An

IPC分类号： A61K39/395

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/92

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US20110052597A1

公开(公告)日：2011-03-03

申请号：US12445753

申请日：2007-10-19

申请人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

发明人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

IPC分类号： A61K39/395 ,  C07K16/24 ,  C12N15/63 ,  C12N5/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P1/00 ,  A61P19/02

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibody antagonists of human interleukin-13 receptor alpha 1 which bind to hIL-13Rα1 through domain 3 of the extracellular region of the receptor and inhibit IL-13 receptor-mediated signaling by IL-13 are disclosed herein. These antibodies have uses inter alia in the treatment or prevention of IL-13-related disorders and diseases. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing hIL-13Rα1-mediated activities are also disclosed.

摘要翻译： 本文公开了通过受体的细胞外区的结构域3结合hIL-13Rα1和IL-13受体介导的信号传导的人白细胞介素-13受体α1的抗体拮抗剂。 这些抗体尤其用于治疗或预防IL-13相关疾病和疾病。 本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。 还公开了使用抗体分子抑制或拮抗hIL-13Rα1介导的活性的方法。

公开(公告)号：US07811563B2

公开(公告)日：2010-10-12

申请号：US11577426

申请日：2005-10-21

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDL的组装和酪氨酸磷酸化，并且在用于预防和治疗与淀粉样蛋白和可溶性蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US20090285799A1

公开(公告)日：2009-11-19

申请号：US12445759

申请日：2007-10-19

申请人： Andrew Donald Nash ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

发明人： Andrew Donald Nash ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are useful in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.

摘要翻译： 公开了人白细胞介素-13受体α1的抗体拮抗剂。 抗体分子可用于抑制IL-13Rα1介导的活性，因此，可用于治疗与hIL-13Rα1活性相关的病症中所需的拮抗剂。 本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。 还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。

公开(公告)号：US20080175835A1

公开(公告)日：2008-07-24

申请号：US11577426

申请日：2005-10-21

申请人： Paul Acton ,  Zhigiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

发明人： Paul Acton ,  Zhigiang An ,  Andrew J. Bett ,  Robert Breese ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola ,  Lei Chang

IPC分类号： A61K39/395 ,  C07K16/44 ,  G01N33/536 ,  C12N9/12 ,  G01N33/53 ,  A61P25/28

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tauphosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异地识别Abeta衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDL的组装和Tauphosphorylation，并且在用于预防和治疗与淀粉样蛋白β1-42的可溶性低聚物相关的疾病的方法中是有用的。

公开(公告)号：US20100285035A1

公开(公告)日：2010-11-11

申请号：US12774966

申请日：2010-05-06

申请人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

发明人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07H21/04 ,  A61P35/00 ,  A61P1/00 ,  A61P17/06 ,  A61P11/06 ,  A61P37/08 ,  A61P29/00 ,  A61P17/00 ,  C12N15/60 ,  C12N5/10

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/43 ,  C12P21/005

摘要： High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.

摘要翻译： 公开了人白细胞介素-13受体α1的高亲和力抗体拮抗剂。 抗体分子在抑制IL-13Rα1介导的活性中是有效的，因此，在治疗与hIL-13Rα1活性相关的病症中使用所需的拮抗剂。 本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。 还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。

公开(公告)号：US20100272714A1

公开(公告)日：2010-10-28

申请号：US12828411

申请日：2010-07-01

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N5/02 ,  G01N33/53

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本发明的抗体还阻断ADDL与神经元的结合，ADDL的组装和tau磷酸化，并且在预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。

公开(公告)号：US07780963B2

公开(公告)日：2010-08-24

申请号：US11256332

申请日：2005-10-21

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kirsten Viola

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本抗体还阻断ADDL与神经元的结合，ADDLS的组装和tau磷酸化，并且在用于预防和治疗与淀粉样蛋白1-42的可溶性低聚物相关的疾病的方法中是有用的。

公开(公告)号：US20080166343A1

公开(公告)日：2008-07-10

申请号：US11875017

申请日：2007-10-19

申请人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

发明人： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  A61P43/00

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/43 ,  C12P21/005

摘要： High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.

摘要翻译： 公开了人白细胞介素-13受体α1的高亲和力抗体拮抗剂。 抗体分子在抑制IL-13Rα1介导的活性中是有效的，因此，在治疗与hIL-13Rα1活性相关的病症中使用所需的拮抗剂。 本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。 还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。

公开(公告)号：US08128930B2

公开(公告)日：2012-03-06

申请号：US12828411

申请日：2010-07-01

申请人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

发明人： Paul Acton ,  Zhiqiang An ,  Andrew J. Bett ,  Robert Breese ,  Lei Chang ,  Elizabeth Chen Dodson ,  Gene Kinney ,  William L. Klein ,  Mary P. Lambert ,  Xiaoping Liang ,  Paul Shughrue ,  William R. Strohl ,  Kristen Viola

IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53

CPC分类号： G01N33/5058 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2814 ,  G01N2800/2821

摘要： The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.

摘要翻译： 本发明涉及差异识别衍生的可扩散配体（也称为ADDL）的多维构象的抗体。 本发明的抗体可以区分阿尔茨海默病和对照人脑提取物，并且可用于检测ADDL和诊断阿尔茨海默病的方法。 本发明的抗体还阻断ADDL与神经元的结合，ADDL的组装和tau磷酸化，并且在预防和治疗与淀粉样蛋白的可溶性低聚物相关的疾病的方法中是有用的。 1-42。