The present invention relates to a method and apparatus for generating pressure suitable in magnitude for powering micro-sized devices. The present invention typically comprises a gas generation chamber that is equipped with an activation element and filled with a gas-containing liquid. Powering of the activation element causes gas within the liquid to be released. Upon release a series of pressure distribution channels deliver the gas to a wide variety of peripheral microfluidic devices. A series of one-way valves and multi-chambered configurations allow for a wide variety of pressures to be generated from a single pressure generation device. By manipulating the scale of the pressure generation device, lab-on-chip, hand held, and bench top applications are possible and may readily be interfaced to allow a substantial amount of user control of the system.