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1.发明申请INTRINSIC FREQUENCY ANALYSIS FOR LEFT VENTRICLE EJECTION FRACTION OR STROKE VOLUME DETERMINATION 有权用于左心室射血分数或排气量测定的内在频率分析公开(公告)号：US20150112219A1
公开(公告)日：2015-04-23
申请号：US14517702
申请日：2014-10-17
CPC分类号： A61B5/1128 , A61B5/0004 , A61B5/0013 , A61B5/02028 , A61B5/021 , A61B5/02405 , A61B5/0261 , A61B5/029 , A61B5/1102 , A61B5/7235 , A61B5/7278 , A61B5/7282 , A61B8/065 , A61B8/5223 , A61B2562/0228
摘要： Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination.
摘要翻译： 硬件和软件方法被描述为非侵入性地监测心脏健康。 分析针对受试者各种获得的血流动力学波形，以计算或近似跨越Dicrotic Notch的两个域中的两个域中的固有频率。 与相关的切口定时一起，可以确定心率和血压值左心室射血分数和/或冲程体积。
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2.发明授权Method of manufacturing an implantable drug delivery system including an impedance pump 有权制造包括阻抗泵的可植入药物递送系统的方法公开(公告)号：US08945448B2
公开(公告)日：2015-02-03
申请号：US13491385
申请日：2012-06-07
CPC分类号： A61M5/14276 , A61M5/14224 , A61M37/00 , A61M2205/8206 , A61M2205/8212 , A61M2205/8243 , A61M2207/00 , A61M2210/0612 , A61M2210/0662 , A61M2210/0693 , G01F11/08
摘要： Described herein are systems, devices, and methods for the delivery of substances to, or the sampling of substances from, a patient using a portable and preferably implantable device. The substances introduced to and/or taken from the patient are preferably fluidic and are driven by a miniature pump, such as a microimpedance pump. A number of design variations are explicitly and implicitly described, such as the use of multiple pumps and multiple reservoirs for containing medicaments. Methods of manufacture of these systems and devices are also described, for instance, using molding, micromachining, or lithographic processes.
摘要翻译： 本文描述了用于使用便携式和优选可植入装置向患者输送物质或从其中取样物质的系统，装置和方法。 引入和/或从患者取出的物质优选是流体性的，并且由诸如微阻抗泵的微型泵驱动。 明确和隐含地描述了许多设计变化，例如使用多个泵和多个储存器来容纳药物。 还描述了这些系统和装置的制造方法，例如使用成型，微加工或光刻工艺。
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公开(公告)号：US07749152B2
公开(公告)日：2010-07-06
申请号：US11329410
申请日：2006-01-09
申请人： Morteza Gharib , Derek Rinderknecht , Idit Avrahami , Brad Sharp
发明人： Morteza Gharib , Derek Rinderknecht , Idit Avrahami , Brad Sharp
IPC分类号： A61N1/362
CPC分类号： A61M1/12 , A61M1/1067
摘要： A pump installed inside a graft in a body such as the human body to force fluid such as blood through that graft. The pump can be one which operates totally from the outside of the graft, forcing fluid through the graft without extending inside the graft. The pump can be an impedance pump, that operates based on the fluidic mismatches between the graft, and other fluid carrying vessels within the human body.
摘要翻译： 安装在诸如人体的体内的移植物内的泵，以通过该移植物迫使诸如血液的流体。 泵可以是完全从移植物外侧操作的泵，迫使流体通过移植物而不在移植物内延伸。 泵可以是阻抗泵，其基于移植物和人体内其他流体携带血管之间的流体错配进行操作。
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公开(公告)号：US20060196642A1
公开(公告)日：2006-09-07
申请号：US11320167
申请日：2005-12-27
IPC分类号： F28D15/00
CPC分类号： H01L23/473 , H01L2924/0002 , H01L2924/3011 , H01L2924/00
摘要： A heat producing device is placed in contact with a heat exchanger that is fluidically coupled to a fluid pump. The fluid pump operates to pumps fluid through a closed fluidic system between the heat exchanger and a spot where the heat can be dissipated. In an aspect, an actuator forces fluid to be pumped without passing through a wall of the pump. One aspect uses an impedance pump as the pumping element.
摘要翻译： 发热装置被放置成与流体耦合到流体泵的热交换器接触。 流体泵操作以将流体泵送在热交换器和可以消散热量的点之间的封闭流体系统中。 在一方面，致动器迫使流体被泵送而不通过泵的壁。 一方面使用阻抗泵作为泵送元件。
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5.发明授权Method for selectively anchoring and exposing large numbers of nanoscale structures 有权选择性锚定和暴露大量纳米尺度结构的方法公开(公告)号：US08846143B2
公开(公告)日：2014-09-30
申请号：US13110877
申请日：2011-05-18
CPC分类号： B32B37/025 , A61M37/0015 , B01D46/546 , B08B17/065 , B29C70/64 , B29K2105/162 , B32B37/06 , B32B37/12 , B32B2037/1253 , B32B2305/72 , B32B2310/0806 , B32B2313/04 , B32B2398/20 , B63B1/32 , B82B3/0014 , B82B3/0047 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B32/174 , C01B32/18 , C01B2202/08 , F28F13/185 , Y10S977/742 , Y10S977/753 , Y10T428/23979 , Y10T428/24273 , Y10T428/249924
摘要： Methods for fastening nanoscale structures within an anchoring structure to form a nanostructure composite and nanostructure composites formed therefrom. A primary fluid layer is formed on an anchoring substrate. Nanostructures are provided on an initial substrate, the nanostructures having a defined height and orientation with respect to the initial substrate. The nanostructures are introduced to a desired depth in the primary fluid layer, such that the orientation of the nanostructures relative to the growth substrate is substantially maintained. The primary fluid layer comprises one or more fluid layers. Ones of multiple fluid layers are selected such that when altered to form an anchoring structure, a portion of the anchoring structure can be removed, permitting exposure of at least a portion of the nanostructures from the anchoring structure in which they are affixed. The growth substrate is removed. Ends or other parts of nanostructures may be exposed from the anchoring structure.
摘要翻译： 将纳米尺度结构固定在锚固结构内以形成由其形成的纳米结构复合材料和纳米结构复合材料的方法。 主要流体层形成在锚固衬底上。 纳米结构提供在初始基底上，纳米结构相对于初始底物具有限定的高度和取向。 将纳米结构引入初级流体层中所需的深度，使得纳米结构相对于生长衬底的取向基本上保持。 主流体层包括一个或多个流体层。 选择多个流体层的一部分，使得当改变以形成锚定结构时，可以去除锚定结构的一部分，允许至少一部分纳米结构从其所固定的锚定结构暴露。 除去生长底物。 纳米结构的末端或其他部分可能从锚定结构暴露出来。
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6.发明授权Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion 有权用于集成光收集和能量转换的锚定碳纳米管阵列器件的制造公开(公告)号：US07959969B2
公开(公告)日：2011-06-14
申请号：US12291524
申请日：2008-11-10
CPC分类号： H01L51/444 , B29C70/88 , B29K2105/16 , B29K2105/167 , B29K2995/0018 , B82Y10/00 , B82Y15/00 , B82Y20/00 , B82Y30/00 , C01B31/022 , C01B32/158 , C08J5/005 , H01L51/0048 , H01L51/0049 , H01L51/4253 , Y02E10/549 , Y10S977/742 , Y10S977/753 , Y10T428/23921 , Y10T428/23957 , Y10T428/23979 , Y10T428/24355 , Y10T428/30
摘要： A method of fabricating optical energy collection and conversion devices using carbon nanotubes (CNTs), and a method of anchoring CNT's into thin polymeric layers is disclosed. The basic method comprises an initial act of surrounding a plurality of substantially aligned nanostructures within at least one fluid layer of substantially uniform thickness such that a first end of the plurality of nanostructures protrudes from the fluid layer. Next, the fluid layer is altered to form an anchoring layer, thereby fastening the nanostructures within the primary anchoring layer with the first ends of the nanostructures protruding from a first surface of the primary anchoring layer. Finally, a portion of the anchoring layer is selectively removed such that a second end of the nanostructures is exposed and protrudes from the anchoring layer. The resulting product is an optically absorbent composite material having aligned nanostructures protruding from both sides of an anchoring layer.
摘要翻译： 公开了一种使用碳纳米管（CNT）制造光能收集和转换装置的方法，以及将CNT锚定到薄聚合物层中的方法。 基本方法包括在基本均匀厚度的至少一个流体层内围绕多个基本排列的纳米结构的初始动作，使得多个纳米结构的第一端从流体层突出。 接下来，改变流体层以形成锚定层，从而将纳米结构紧固在主锚定层内，纳米结构的第一端从主锚定层的第一表面突出。 最后，锚定层的一部分被选择性地去除，使得纳米结构的第二端被暴露并从锚定层突出。 所得产品是具有从锚定层的两侧突出的取向的纳米结构的光学吸收复合材料。
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7.发明申请公开(公告)号：US20080060700A1
公开(公告)日：2008-03-13
申请号：US11899721
申请日：2007-09-07
CPC分类号： B01L3/50273 , B01L3/502738 , B01L2300/0816 , B01L2300/14 , B01L2400/0442 , B01L2400/0487 , Y10T137/0379 , Y10T137/0396 , Y10T137/3115 , Y10T137/8593 , Y10T137/87153
摘要： The present invention relates to a method and apparatus for generating pressure suitable in magnitude for powering micro-sized devices. The present invention typically comprises a gas generation chamber that is equipped with an activation element and filled with a gas-containing liquid. Powering of the activation element causes gas within the liquid to be released. Upon release a series of pressure distribution channels deliver the gas to a wide variety of peripheral microfluidic devices. A series of one-way valves and multi-chambered configurations allow for a wide variety of pressures to be generated from a single pressure generation device. By manipulating the scale of the pressure generation device, lab-on-chip, hand held, and bench top applications are possible and may readily be interfaced to allow a substantial amount of user control of the system.
摘要翻译： 本发明涉及一种用于产生适合于为微型设备供电的量级的压力的方法和装置。 本发明通常包括一个装有活化元件并充满含气体液体的气体生成室。 激活元件的动力导致液体内的气体被释放。 在释放时，一系列压力分配通道将气体输送到各种各样的外围微流体装置。 一系列单向阀和多室配置允许从单个压力发生装置产生各种各样的压力。 通过操纵压力发生装置的规模，芯片上的实验室，手持式和台式应用是可能的，并且可以容易地连接以允许对系统的大量用户控制。
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公开(公告)号：US20050275494A1
公开(公告)日：2005-12-15
申请号：US11137853
申请日：2005-05-24
CPC分类号： H02K41/031 , A61M2205/0244 , F04B19/006 , F04B43/043 , F04B43/12 , H02K7/14 , H02K33/16 , H02K99/20
摘要： An electromagnetic actuator for a microfluidic pump of the type that causes periodic pinching and releasing against the walls of a fluidic channel, e.g., a tube. At least one permanent magnet is placed against the walls of the fluidic channel, and located in an area with magnetic fields, produced by coils that are radially symmetric to the channel. The permanent magnet is cause to press and release against the wall of the fluid channel to cause a fluid flow through the channel.
摘要翻译： 用于微流体泵的电磁致动器，其导致周期性地夹持和释放抵靠流体通道（例如管）的壁。 至少一个永磁体被放置在流体通道的壁上，并且位于具有与通道径向对称的线圈产生的具有磁场的区域中。 导致永久磁铁压迫和释放流体通道的壁，使流体流过通道。
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公开(公告)号：US07955644B2
公开(公告)日：2011-06-07
申请号：US11827169
申请日：2007-07-10
CPC分类号： B29C70/64 , B29K2105/162 , B81C3/008 , B81C2201/034 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B32/18 , C01B2202/08 , Y10S977/742 , Y10S977/753 , Y10T156/109 , Y10T428/24479
摘要： A method is provided for creating composites by combining pre-fabricated nanoscale structures (nanostructures) and other materials in which the nanostructures are anchored. This method results in anchored nanostructures with their base held and encased within the anchoring material to a specified depth and with a specified length of protrusion of the nanostructures from the anchoring material. This represents a major advance over previous methods of creating composites containing nanostructures which were limited to fully embedded nanostructures or, at best, very limited and uncontrolled protrusion of nanostructures. In summary, the current method involves bringing nanostructures and anchoring materials into physical contact in a controlled fashion and optionally conducting a treatment step to complete the anchoring process.
摘要翻译： 提供了一种通过组合预制纳米尺度结构（纳米结构）和其中纳米结构被锚定的其它材料来产生复合材料的方法。 该方法导致锚定的纳米结构，其基部保持并且被包裹在锚固材料内到达指定的深度并且具有来自锚定材料的纳米结构的特定长度的突出。 这代表了先前创建含有纳米结构的复合材料的方法的重大进步，这些纳米结构限于完全嵌入的纳米结构，或者至多是非常有限的和不受控制的纳米结构突起。 总之，目前的方法涉及使纳米结构和锚定材料以受控的方式物理接触，并且可选地进行处理步骤以完成锚定过程。
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公开(公告)号：US20110125136A1
公开(公告)日：2011-05-26
申请号：US13013733
申请日：2011-01-25
CPC分类号： B01L3/50273 , B01L2200/10 , B01L2300/0864 , B01L2400/0439 , B01L2400/0481 , B01L2400/082 , B01L2400/084 , G01N2035/00148 , G01N2035/1034
摘要： A device and methods for continuous precision blood sampling from a patient with a micro impedance pump as the driver in a microfluidic system. Depending on the needs of medical technologies, the micro impedance pump in the intravascular diagnostic and therapeutic sampling system serves in a forward pumping function for blood sampling, in a backward infusing for therapeutic treatment, and in a valving function for controlling fluid flow.
摘要翻译： 用于在微流体系统中作为驱动器的微阻抗泵的患者进行连续精确采血的装置和方法。 根据医疗技术的需要，血管内诊断和治疗取样系统中的微阻抗泵用于血液采样的正向泵送功能，用于治疗性治疗的反向输注以及用于控制流体流动的阀门功能。
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