发明授权
US07763451B2 Methods for preparing Bacillus anthracis protective antigen for use in vaccines
有权
制备用于疫苗的炭疽芽孢杆菌保护性抗原的方法
- 专利标题： Methods for preparing Bacillus anthracis protective antigen for use in vaccines
- 专利标题（中）： 制备用于疫苗的炭疽芽孢杆菌保护性抗原的方法
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申请号： US10290712申请日： 2002-11-08
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公开(公告)号： US07763451B2公开(公告)日： 2010-07-27
- 发明人: Joseph Shiloach , Stephen H. Leppla , Delia M. Ramirez , Rachel Schneerson , John B. Robbins , S. Dana Hsu , Mary Jo Rosovitz
- 申请人： Joseph Shiloach , Stephen H. Leppla , Delia M. Ramirez , Rachel Schneerson , John B. Robbins , S. Dana Hsu , Mary Jo Rosovitz
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Klarquist Sparkman, LLP
- 主分类号： C12N1/00
- IPC分类号： C12N1/00 ; C12N1/20 ; C12P1/00 ; A61K39/38 ; A61K39/02 ; A61K39/07
摘要：
The invention relates to improved methods of producing and recovering B. anthracis protective antigen (PA), especially modified PA which is protease resistant, and to methods of using of these PAs or nucleic acids encoding these PAs for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, B. anthracis bacterial infections and which are useful to prevent and/or treat illnesses caused by B. anthracis, such as inhalation anthrax, cutaneous anthrax and gastrointestinal anthrax.
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