发明授权
- 专利标题: Pyrrole derivatives as antimycobacterial compounds
- 专利标题(中): 吡咯衍生物作为抗分枝杆菌化合物
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申请号: US12137170申请日: 2008-06-11
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公开(公告)号: US07763602B2公开(公告)日: 2010-07-27
- 发明人: Sudershan Kumar Arora , Neelima Sinha , Sanjay Jain , Ram Shankar Upadhayaya , Gourhari Jana , Shankar Ajay , Rakesh Kumar Sinha
- 申请人: Sudershan Kumar Arora , Neelima Sinha , Sanjay Jain , Ram Shankar Upadhayaya , Gourhari Jana , Shankar Ajay , Rakesh Kumar Sinha
- 申请人地址: IN Mumbai
- 专利权人: Lupin Limited
- 当前专利权人: Lupin Limited
- 当前专利权人地址: IN Mumbai
- 代理机构: Merchant & Gould P.C.
- 主分类号: A01N43/00
- IPC分类号: A01N43/00 ; A01N43/36 ; A01N43/50 ; A01N43/62 ; A01N43/76 ; A61K31/00 ; A61K31/40 ; A61K31/415 ; A61K31/42 ; A61K31/425 ; A61K31/445 ; A61K31/497 ; A61K31/535 ; A61K31/54 ; A61K31/55
摘要:
Novel pyrrole derivatives of formula (I) and their pharmaceutically acceptable acid addition salts having superior antimycobacterial activity against clinically sensitive as well as resistant strains of Mycobacterium tuberculosis as well as having lesser toxicity compared to known compounds. The use of the novel compounds of formula (I) for treatment of latent tuberculosis including Multi Drug Resistant Tuberculosis (MDR TB). The methods for preparation of the novel compounds, pharmaceutical compositions containing the novel compounds and method of treating MDR TB by administration of compounds of formula (I).
公开/授权文献
- US20080242676A1 PYRROLE DERIVATIVES AS ANTIMYCOBACTERIAL COMPOUNDS 公开/授权日:2008-10-02
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