A surgical stapling instrument including an actuator knob which can be moved from one side of the stapling instrument to another side in order to reposition the actuator knob without having to reposition the stapling instrument within a surgical site. A stapling instrument can include a pusher bar, a housing having a first side and a second side, and an actuator knob rotatably mounted to the pusher bar wherein the actuator knob can be configured to be rotated between a first position in which the actuator knob can be moved along the first side of the housing and a second position where the actuator knob can be moved along a second side of the housing. Alternatively, a surgical stapling instrument can comprise one or more actuator knobs which can be operably engaged and disengaged with a pusher bar in order to selectively utilize the actuator knobs.