Invention Grant
US07767432B2 Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B
有权
埃坡霉素B的制备，分离和纯化方法以及埃坡霉素B的X射线晶体结构
- Patent Title: Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B
- Patent Title (中): 埃坡霉素B的制备，分离和纯化方法以及埃坡霉素B的X射线晶体结构
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Application No.: US11669268Application Date: 2007-01-31
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Publication No.: US07767432B2Publication Date: 2010-08-03
- Inventor: Brian L. Davis
- Applicant: Brian L. Davis
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Hong Liu; Anastasia P. Winslow
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12P17/14
Abstract:
The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.
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