Invention Grant
- Patent Title: Spiroketal derivatives and use thereof as diabetic medicine
- Patent Title (中): 螺缩酮衍生物及其作为糖尿病药物的用途
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Application No.: US11815074Application Date: 2006-01-27
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Publication No.: US07767651B2Publication Date: 2010-08-03
- Inventor: Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
- Applicant: Takamitsu Kobayashi , Tsutomu Sato , Masahiro Nishimoto
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Browdy and Neimark, PLLC
- Priority: JP2005-020901 20050128; JP2005-176690 20050616
- International Application: PCT/JP2006/301284 WO 20060127
- International Announcement: WO2006/080421 WO 20060803
- Main IPC: A01N43/04
- IPC: A01N43/04 ; C07H1/00 ; C07H3/00 ; C08B37/00

Abstract:
The present invention provides a compound of Formula (I): wherein R1, R2, R3 and R4 are each independently selected from a hydrogen atom, an optionally substituted C1-C6 alkyl group, an optionally substituted C7-C14 aralkyl group and —C(═O)Rx; Rx represents an optionally substituted C1-C6 alkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted C1-C6 alkoxy group or —NReRf; Ar1 represents an optionally substituted aromatic carbocyclic ring or an optionally mono-substituted aromatic heterocyclic ring; Q represents —(CH2)m-(L)p- or -(L)p-(CH2)m—; m represents an integer selected from 0 to 2, n represents an integer selected from 1 and 2, and p represents an integer selected from 0 and 1; L represents —O—, —S— or —NR5—; and A represents an optionally substituted aryl group or an optionally substituted heteroaryl group, a prodrug thereof and a pharmaceutically acceptable salt thereof, as well as a pharmaceutical preparation or pharmaceutical composition comprising such a compound.
Public/Granted literature
- US20090030006A1 SPIROKETAL DERIVATIVES AND USE THEREOF AS DIABETIC MEDICINE Public/Granted day:2009-01-29
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