Invention Grant
US07767799B2 Nucleic acid molecules encoding recombinant interferon-α2 (IFNα2) mutants
有权
编码重组干扰素-α2（IFNα2）突变体的核酸分子
- Patent Title: Nucleic acid molecules encoding recombinant interferon-α2 (IFNα2) mutants
- Patent Title (中): 编码重组干扰素-α2（IFNα2）突变体的核酸分子
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Application No.: US11994159Application Date: 2006-06-28
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Publication No.: US07767799B2Publication Date: 2010-08-03
- Inventor: Gideon E Schreiber , Laila C. Roisman , Diego Jaitin , Eyal Kalie
- Applicant: Gideon E Schreiber , Laila C. Roisman , Diego Jaitin , Eyal Kalie
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
- Current Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
- Current Assignee Address: IL Rehovot
- Agency: Winston & Strawn LLP
- International Application: PCT/IL2006/000754 WO 20060628
- International Announcement: WO2007/000769 WO 20070104
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
The present invention provides IFNα2 mutants and active fragments, analogs, derivatives, and variants thereof that have improved specific agonist or antagonist activity as compared to wild-type IFNα2. The present invention further provides pharmaceutical compositions comprising IFNα2 mutants useful for treating or preventing cancer, autoimmune diseases, infectious diseases or disorders associated with increased expression of IFNα2.
Public/Granted literature
- US20080279823A1 Recombinant Interferon 2alpha (Infalpha2) Mutants Public/Granted day:2008-11-13
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