公开(公告)号：US20240069042A1

公开(公告)日：2024-02-29

申请号：US18387593

申请日：2023-11-07

申请人： NeuroQuest Ltd. ,  Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

发明人： Xin Huang ,  Yihan Li ,  James Doecke ,  Michal Eisenbach-Schwartz ,  Baijun Gu

IPC分类号： G01N33/68 ,  G01N33/58

CPC分类号： G01N33/6896 ,  G01N33/582 ,  G01N2800/2821

摘要： Compositions and kits for diagnosing and prognosing Alzheimer's Disease (AD) in a human patient include a binding agent such as a monoclonal antibody for a biomarker conjugated to a detectable moiety such as a fluorophore, wherein the biomarker is chosen from CD11c, CD59, CD91, and CD163 and other phagocytosis-related molecules. Further compositions and kits employ panels of fluorophore-conjugated monoclonal antibodies for biomarkers including scavenger receptors. Methods for determining the relative expression of biomarkers, diagnosing AD, and determining the efficacy of AD therapeutic candidates such as phagocytosis-promoting agents and scavenger receptor agonists also appear.

公开(公告)号：US20220031776A1

公开(公告)日：2022-02-03

申请号：US16644641

申请日：2018-09-07

申请人： Keio University ,  BiomX Ltd. ,  Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

发明人： Kenya Honda ,  Koji Atarashi ,  Seiko Narushima ,  Eran Elinav ,  Rotem Sorek ,  Efrat Khabra ,  Hava Ben David ,  Eyal Weinstock ,  Sarah Pollock ,  Yulia Matiuhin ,  Naomi Zak

IPC分类号： A61K35/76 ,  C12N7/00

摘要： Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.

公开(公告)号：US10159724B2

公开(公告)日：2018-12-25

申请号：US15286327

申请日：2016-10-05

申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE ,  UNIVERSITAET DUISBURG-ESSEN

发明人： Edward H. Schuchman ,  Erich Gulbins ,  Anthony Futerman ,  Yael Pewzner-Jung

IPC分类号： A61K38/50 ,  A61K9/12 ,  A61K9/00 ,  A61K45/06

摘要： The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.

公开(公告)号：US09966458B2

公开(公告)日：2018-05-08

申请号：US15178951

申请日：2016-06-10

申请人： Westfälische Wilhelms Universität Münster ,  Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science

发明人： Benjamin Göhler ,  Volker Hamelbeck ,  G. Friedrich Hanne ,  Helmut Zacharias ,  Ron Naaman ,  Tal Zvi Markus

IPC分类号： H01L29/66 ,  B82Y10/00 ,  H01L51/00 ,  H01L51/05

CPC分类号： H01L29/66984 ,  B82Y10/00 ,  H01L51/0093 ,  H01L51/0595

摘要： The present invention relates to a method and a device for providing a current of spin-polarized electrons. More particularly, the present invention is suited for use in spin electronics or detection of spin-polarized electrons.

公开(公告)号：US09067052B2

公开(公告)日：2015-06-30

申请号：US13254361

申请日：2010-03-02

申请人： Elisha Moses ,  Assaf Rotem

发明人： Elisha Moses ,  Assaf Rotem

IPC分类号： A61N1/00 ,  A61N2/00 ,  A61N1/36 ,  A61N2/02 ,  A61N1/08 ,  A61N1/40

CPC分类号： A61N2/006 ,  A61B5/0484 ,  A61B5/4836 ,  A61N1/08 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/40 ,  A61N2/02

摘要： Transcranial magnetic stimulation (TMS) is a remarkable tool for probing the brain. However, it is still unclear why specific regions in the cortex are excitable by TMS while others are not. This invention provides methods and tools for the design of efficient magnetic stimulators. Such stimulators can excite neuronal networks that were not sensitive to stimulation until now. Stimulation can be carried out both in-vitro and in-vivo. Novel systems and techniques of this invention will enable both treatment and diagnostics by stimulating regions of the brain or neuronal assemblies that were previously unaffected by TMS.

摘要翻译： 经颅磁刺激（TMS）是探索大脑的显着工具。 然而，仍然不清楚为什么皮质中的特定区域可被TMS兴奋，而其他区域则不是。 本发明提供了用于设计有效的磁刺激器的方法和工具。 这种刺激器可以激发到目前为止对刺激不敏感的神经元网络。 刺激可以在体外和体内进行。 本发明的新型系统和技术将能够通过刺激先前未受TMS影响的脑或神经元组件的区域来实现治疗和诊断。

公开(公告)号：US20110301093A1

公开(公告)日：2011-12-08

申请号：US13152270

申请日：2011-06-03

申请人： Adi Kimchi ,  Einat Zalckvar

发明人： Adi Kimchi ,  Einat Zalckvar

IPC分类号： A61K38/17 ,  C40B30/00 ,  C12Q1/68 ,  C07K14/47 ,  C07H21/00 ,  A61P35/00 ,  C12N7/01 ,  C12N5/10 ,  C12N1/00 ,  G01N33/577 ,  C12N15/85 ,  G01N33/574 ,  C12N15/63

CPC分类号： G01N33/6872 ,  C07K16/44 ,  G01N2440/14 ,  G01N2500/02

摘要： The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases.

公开(公告)号：US20110093986A1

公开(公告)日：2011-04-21

申请号：US12999814

申请日：2009-06-28

申请人： Asaph Aharoni ,  Avital Adato ,  Tali Mandel

发明人： Asaph Aharoni ,  Avital Adato ,  Tali Mandel

IPC分类号： A01H5/00 ,  C07H21/04 ,  C07H21/00 ,  C12Q1/68

CPC分类号： C12N15/825 ,  C07K14/415 ,  C12Q1/6895 ,  C12Q2600/156

摘要： The present invention discloses that down regulation of the SlMYB12 transcription factor results in the colorless peel y phenotype in tomato fruit. The present invention provides polynucleotides encoding the tomato SlMYB12 transcription factor and genetic markers derived therefrom, useful in the breeding of tomato plants having the colorless peel phenotype and in the production of transgenic plants having altered flavonoid content.

摘要翻译： 本发明公开了SlMYB12转录因子的下调，导致番茄果实无色果皮表型。 本发明提供了编码番茄S1MYB12转录因子的多核苷酸和从其衍生的遗传标记，其可用于育种具有无色剥离表型的番茄植物和在具有改变的类黄酮含量的转基因植物的生产中。

公开(公告)号：US07741021B2

公开(公告)日：2010-06-22

申请号：US11595319

申请日：2006-11-09

申请人： Alma L. Burlingame ,  Katalin F. Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert J. Chalkley ,  Darren Tyson ,  Ralph A. Bradshaw

发明人： Alma L. Burlingame ,  Katalin F. Medzihradszky ,  Zsuzsanna Darula ,  Eran Perlson ,  Michael Fainzilber ,  Robert J. Chalkley ,  Darren Tyson ,  Ralph A. Bradshaw

IPC分类号： C12Q1/00 ,  C12Q1/48 ,  C12Q1/37

CPC分类号： G01N33/6842 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/6803

摘要： Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions.Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.

摘要翻译： 检测蛋白质丝氨酸或苏氨酸残基的翻译后O-磺化，任选比较，其中在第一生理条件下检测到检测到的O-磺化，并与在第二生理条件下检测到的对照O-磺化进行比较， 并且检测到和控制的O-磺化物之间的差异表示第一和第二生理条件之间的差异。 使用生理条件的预定变化来推测O-磺化的具体变化。 通过在蛋白质的丝氨酸或苏氨酸残基处引入O-磺化的预定变化，并任选地检测所得到的O-磺化变化来修饰蛋白质。 这些方法包括引入或增加O-磺化，消除或减少O-磺化; 并衍生化或取代O-磺化。

公开(公告)号：US20100003225A1

公开(公告)日：2010-01-07

申请号：US11813333

申请日：2006-01-04

申请人： Irun R. Cohen ,  Alexandra Zanin-Zhorov ,  Guy Tal ,  Francisco Quintana ,  Meirav Pevsner ,  Ofer Lider ,  Osnat Lider ,  Lihi Lider

发明人： Irun R. Cohen ,  Alexandra Zanin-Zhorov ,  Guy Tal ,  Francisco Quintana ,  Meirav Pevsner ,  Ofer Lider ,  Osnat Lider ,  Lihi Lider

IPC分类号： A61K45/00 ,  A61K38/16 ,  A61K31/7088 ,  A61P1/16 ,  A61P31/12

CPC分类号： A61K38/1709 ,  A61K35/17 ,  A61K39/0008 ,  A61K2035/124 ,  A61K2039/5158 ,  A61K2039/53 ,  C12N5/0636 ,  C12N2501/07

摘要： The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.

摘要翻译： 本发明提供了人类热休克蛋白60（HSP60）的肽p277-位置437-460在调节免疫应答和炎性疾病方面的新用途。 本发明进一步提供HSP60和p277在治疗或预防肝病中的新用途。 本发明公开了治疗，预防或改善T细胞介导的炎症和自身免疫性疾病（包括肝脏疾病）的症状的方法，其包括向有需要的受试者施用包含有效量的选自以下的分子的组合物： HSP60，p277，其片段，类似物，同源物及其衍生物，以及编码其的核酸。 还公开了用于治疗或预防T细胞介导的病症的T细胞疫苗接种方法。

公开(公告)号：US20080311103A1

公开(公告)日：2008-12-18

申请号：US10592163

申请日：2005-03-08

申请人： Ofer Lider ,  Liora Cahalon ,  Osnat Lider ,  Lihi Lider

发明人： Ofer Lider ,  Liora Cahalon ,  Osnat Lider ,  Lihi Lider

IPC分类号： A61K38/43 ,  C12N9/50 ,  A61P29/00

CPC分类号： A61K35/24 ,  A61K38/1709 ,  A61K38/177 ,  A61K38/363 ,  A61K38/4886

摘要： Anti-inflammatory peptides derived from naturally occurring digests of proteins including apolipoprotein A-I, apolipoprotein A-II, fibrinogen γ chain, fibrinogen Aa, low-density lipoprotein receptor, ADAM 8, cadherin 4, and calcitonin receptor are provided, along with pharmaceutical compositions comprising same and methods of treating inflammatory diseases using same.

摘要翻译： 提供衍生自天然存在的蛋白质消化物质的抗炎肽，包括载脂蛋白AI，载脂蛋白A-II，纤维蛋白原γ链，纤维蛋白原Aa，低密度脂蛋白受体，ADAM8，钙粘蛋白4和降钙素受体。 相同的治疗炎症性疾病的方法。