Invention Grant
- Patent Title: Process for preparing renin inhibitors
- Patent Title (中): 制备肾素抑制剂的方法
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Application No.: US11916875Application Date: 2006-06-06
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Publication No.: US07767831B2Publication Date: 2010-08-03
- Inventor: Stuart J Mickel , Gottfried Sedelmeier , Hans Hirt , Frank Schäfer , Michael Foulkes , Walter Prikoszovich
- Applicant: Stuart J Mickel , Gottfried Sedelmeier , Hans Hirt , Frank Schäfer , Michael Foulkes , Walter Prikoszovich
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Dilworth & Barrese, LLP
- Agent Ann R. Pokalsky, Esq.
- Priority: GB0511686.8 20050608
- International Application: PCT/EP2006/005370 WO 20060606
- International Announcement: WO2006/131304 WO 20061214
- Main IPC: C07D207/08
- IPC: C07D207/08
Abstract:
The present invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention provides a process for the manufacture of a compound of the formula III, wherein R, R1, R2, R3 and PG are as defined in the specification, or a salt thereof. The manufacture comprises (preferably consists of) reacting a compound of the formula I, with a reagent able to transform hydroxy into X where X is for example a leaving group.
Public/Granted literature
- US20080207921A1 Organic Compounds Public/Granted day:2008-08-28
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