发明授权
US07776868B2 Substituted bicyclic and tricyclic thieno[2,3-d]pyrimidines as A2A adenosine receptor antagonists
有权
取代的双环和三环噻吩并[2,3-d]嘧啶作为A2A腺苷受体拮抗剂
- 专利标题: Substituted bicyclic and tricyclic thieno[2,3-d]pyrimidines as A2A adenosine receptor antagonists
- 专利标题(中): 取代的双环和三环噻吩并[2,3-d]嘧啶作为A2A腺苷受体拮抗剂
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申请号: US11947690申请日: 2007-11-29
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公开(公告)号: US07776868B2公开(公告)日: 2010-08-17
- 发明人: Tetsuya Kobayashi , Rao Kalla , Elfatih Elzein , Jeff Zablocki , Brent Blackburn
- 申请人: Tetsuya Kobayashi , Rao Kalla , Elfatih Elzein , Jeff Zablocki , Brent Blackburn
- 申请人地址: US CA Foster City
- 专利权人: Gilead Palo Alto, Inc.
- 当前专利权人: Gilead Palo Alto, Inc.
- 当前专利权人地址: US CA Foster City
- 代理商 J. Elin Hartrum
- 主分类号: C07D495/04
- IPC分类号: C07D495/04 ; A61K31/519 ; A61P25/28 ; A61P25/24 ; A61P3/04 ; A61P37/02
摘要:
The present invention relates to novel compounds that are A2A adenosine receptor antagonists having the structure of Formula I and to their use in treating mammals for various disease states, such as obesity, CNS disorders, including the “movement disorders” (Parkinson's disease, Huntington's Chorea, and catelepsy), and cerebral ischemia, excitotoxicity, cognitive and physiological disorders, depression, ADHD, and drug addiction (alcohol, amphetamine, cannabinoids, cocaine, nicotine, and opioids) and to their use in the enhancement of immune response. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
公开/授权文献
- US20080188495A1 A2A ADENOSINE RECEPTOR ANTAGONISTS 公开/授权日:2008-08-07
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