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    Substituted bicyclic and tricyclic thieno[2,3-d]pyrimidines as A2A adenosine receptor antagonists
    1.
    发明授权
    Substituted bicyclic and tricyclic thieno[2,3-d]pyrimidines as A2A adenosine receptor antagonists 有权
    取代的双环和三环噻吩并[2,3-d]嘧啶作为A2A腺苷受体拮抗剂

    公开(公告)号：US07776868B2

    公开(公告)日：2010-08-17

    申请号：US11947690

    申请日：2007-11-29

    申请人： Tetsuya Kobayashi ,  Rao Kalla ,  Elfatih Elzein ,  Jeff Zablocki ,  Brent Blackburn

    发明人： Tetsuya Kobayashi ,  Rao Kalla ,  Elfatih Elzein ,  Jeff Zablocki ,  Brent Blackburn

    IPC分类号： C07D495/04 ,  A61K31/519 ,  A61P25/28 ,  A61P25/24 ,  A61P3/04 ,  A61P37/02

    CPC分类号： C07D495/04

    摘要： The present invention relates to novel compounds that are A2A adenosine receptor antagonists having the structure of Formula I and to their use in treating mammals for various disease states, such as obesity, CNS disorders, including the “movement disorders” (Parkinson's disease, Huntington's Chorea, and catelepsy), and cerebral ischemia, excitotoxicity, cognitive and physiological disorders, depression, ADHD, and drug addiction (alcohol, amphetamine, cannabinoids, cocaine, nicotine, and opioids) and to their use in the enhancement of immune response. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及具有式I结构的A2A腺苷受体拮抗剂的新化合物及其用于治疗各种疾病状态的哺乳动物，例如肥胖症，中枢神经系统疾病，包括“运动障碍”（帕金森病，亨廷顿氏舞蹈病 ，和脑损伤）和脑缺血，兴奋性毒性，认知和生理障碍，抑郁症，ADHD和药物成瘾（酒精，苯丙胺，大麻素，可卡因，尼古丁和阿片样物质）及其在增强免疫应答中的用途。 本发明还涉及制备这些化合物的方法以及含有它们的药物组合物。

    A2A ADENOSINE RECEPTOR ANTAGONISTS
    2.
    发明申请
    A2A ADENOSINE RECEPTOR ANTAGONISTS 有权
    A2A腺苷受体拮抗剂

    公开(公告)号：US20080188495A1

    公开(公告)日：2008-08-07

    申请号：US11947690

    申请日：2007-11-29

    申请人： Tetsuya Kobayashi ,  Rao Kalla ,  Elfatih Elzein ,  Jeff Zablocki ,  Brent Blackburn

    发明人： Tetsuya Kobayashi ,  Rao Kalla ,  Elfatih Elzein ,  Jeff Zablocki ,  Brent Blackburn

    IPC分类号： A61K31/519 ,  C07D495/04 ,  A61P1/16 ,  A61P25/30 ,  A61P25/00 ,  A61P25/16

    CPC分类号： C07D495/04

    摘要： The present invention relates to novel compounds that are A2A adenosine receptor antagonists, and to their use in treating mammals for various disease states, such as CNS disorders, including the “movement disorders” (Parkinson's disease, Huntington's Chorea, and catalepsy), and cerebral ischemia, excitotoxicity, cognitive and physiological disorders, depression, ADHD, hepatic fibrosis, cirrhosis of the liver, and drug addiction (alcohol, amphetamine, cannabinoids, cocaine, nicotine, and opioids) and to their use in the enhancement of immune response. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及作为Aβ2A腺苷受体拮抗剂的新化合物及其用于治疗各种疾病状态的哺乳动物，例如CNS障碍，包括“运动障碍”（Parkinson's disease，Huntington's 胆碱和僵住症）和脑缺血，兴奋性毒性，认知和生理障碍，抑郁症，ADHD，肝纤维化，肝硬化和药物成瘾（酒精，苯丙胺，大麻素，可卡因，尼古丁和阿片样物质）及其使用 在增强免疫反应。 本发明还涉及制备这些化合物的方法以及含有它们的药物组合物。

    A2A ADENOSINE RECEPTOR ANTAGONISTS
    10.
    发明申请
    A2A ADENOSINE RECEPTOR ANTAGONISTS 审中-公开
    A2A腺苷受体拮抗剂

    公开(公告)号：US20070208040A1

    公开(公告)日：2007-09-06

    申请号：US11681378

    申请日：2007-03-02

    申请人： Elfatih Elzein ,  Rao Kalla ,  Jeff Zablocki ,  Xiaofen Li ,  Thao Perry ,  Tetsuya Kobayashi ,  Eric Parkhill

    发明人： Elfatih Elzein ,  Rao Kalla ,  Jeff Zablocki ,  Xiaofen Li ,  Thao Perry ,  Tetsuya Kobayashi ,  Eric Parkhill

    IPC分类号： A61K31/519 ,  C07D498/02

    CPC分类号： C07D495/04

    摘要： The present invention relates to novel compounds that are A2A adenosine receptor antagonists, and to their use in treating mammals for various disease states, such as obesity, CNS disorders, including the “movement disorders” (Parkinson's disease, Huntington's Chorea, and catelepsy), and cerebral ischemia, excitotoxicity, cognitive and physiological disorders, depression, ADHD, and drug addiction (alcohol, amphetamine, cannabinoids, cocaine, nicotine, and opioids) and to their use in the enhancement of immune response. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.

    摘要翻译： 本发明涉及作为Aβ2N腺苷受体拮抗剂的新化合物及其用于治疗各种疾病状态的哺乳动物，例如肥胖症，中枢神经系统疾病，包括“运动障碍”（帕金森病） ，亨廷顿氏舞蹈病和睡眠障碍）和脑缺血，兴奋性毒性，认知和生理障碍，抑郁症，ADHD和药物成瘾（酒精，苯丙胺，大麻素，可卡因，尼古丁和阿片样物质）及其在增强免疫反应中的应用 。 本发明还涉及制备这些化合物的方法以及含有它们的药物组合物。