Invention Grant
- Patent Title: Methods for the early diagnosis of ovarian cancer
- Patent Title (中): 卵巢癌早期诊断方法
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Application No.: US11012787Application Date: 2004-12-15
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Publication No.: US07785841B2Publication Date: 2010-08-31
- Inventor: Timothy J. O'Brien
- Applicant: Timothy J. O'Brien
- Applicant Address: US AR Little Rock
- Assignee: Board of Trustees of the University of Arkansas
- Current Assignee: Board of Trustees of the University of Arkansas
- Current Assignee Address: US AR Little Rock
- Agent Benjamin Aaron Adler
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12Q1/00 ; C12Q1/68 ; C12P19/26 ; C12P19/28 ; C12P19/36 ; C12P19/38 ; C12P19/40 ; G01N1/00 ; G01N21/00
Abstract:
The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of PUMP-1 protease (matrix metalloprotease 7). The detected proteases are themselves specifically over-expressed in certain cancers, and their presence may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment.
Public/Granted literature
- US20050158757A1 Methods for the early diagnosis of ovarian cancer Public/Granted day:2005-07-21
Information query
