发明授权
US07786305B2 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
有权
趋化因子受体活性的四氢吡喃基环戊基四氢吡啶并吡啶调节剂
- 专利标题： Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
- 专利标题（中）： 趋化因子受体活性的四氢吡喃基环戊基四氢吡啶并吡啶调节剂
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申请号： US10856012申请日： 2004-05-28
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公开(公告)号： US07786305B2公开(公告)日： 2010-08-31
- 发明人: Richard Jiao , Gregori Morriello , Lihu Yang , Changyou Zhou , Shankaran Kothandaraman , Christopher Moyes
- 申请人： Richard Jiao , Gregori Morriello , Lihu Yang , Changyou Zhou , Shankaran Kothandaraman , Christopher Moyes
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Mark-R. Daniel; James L. McGinnis
- 主分类号： C07D213/00
- IPC分类号： C07D213/00 ; C07C61/06 ; C07C271/00 ; C07C269/00 ; C07C261/00 ; C07D207/30 ; C07C61/20 ; C07C62/08 ; C07C62/34
摘要：
The present invention is directed to compounds of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2. The present invention is also directed to intermediates useful in the preparation of formula I compounds.
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