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123 条记录 (耗时 0.035 秒)

    Soft-gelatin capsule formulation
    1.
    发明授权
    Soft-gelatin capsule formulation 有权
    软明胶胶囊制剂

    公开(公告)号：US08338639B2

    公开(公告)日：2012-12-25

    申请号：US13210556

    申请日：2011-08-16

    申请人： Yukiko Hashitera ,  Ryu Hirata ,  Yasuhiro Harada ,  Ryuji Ueno

    发明人： Yukiko Hashitera ,  Ryu Hirata ,  Yasuhiro Harada ,  Ryuji Ueno

    IPC分类号： C07C61/06 ,  C07C61/20

    CPC分类号： A61K31/352 ,  A61K9/4816 ,  A61K9/4825 ,  A61K9/4858 ,  A61K31/557 ,  A61K31/5575

    摘要： The present invention provides a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which includes: a soft gelatin capsule shell including gelatin and sugar alcohol as a plasticizer, and a mixture including a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.

    摘要翻译： 本发明提供了一种15-酮前列腺素化合物的软明胶胶囊制剂，其包括：软明胶胶囊壳，包括明胶和糖醇作为增塑剂，以及包含15-酮前列腺素化合物和药学上可接受的混合物 装在壳中的车辆。 通过将15-酮 - 前列腺素化合物包封在指定的软明胶胶囊壳中，化合物的稳定性显着提高。

    Sulfonamides
    2.
    发明授权
    Sulfonamides 有权
    磺胺类

    公开(公告)号：US07932420B2

    公开(公告)日：2011-04-26

    申请号：US11986344

    申请日：2008-03-14

    申请人： Robert M. Burk

    发明人： Robert M. Burk

    IPC分类号： C07C61/06

    CPC分类号： C07C311/06 ,  C07C2601/04

    摘要： The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2 is selected from the group consisting of C1-C10 alkyl and (CH2)nOH; R3 is selected from the group consisting of C1-C10 alkyl, heteroaryl, e.g. thienyl, furanyl and pyridyl, phenyl, mono, -di-, tri-substituted phenyl and heteroaryl; R4 and R5 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl hydroxyl; m is 0 or an integer from 1 to 3 and n is an integer of from 1 to 4. These compounds are useful in lowering intraocular pressure and/or treating glaucoma or providing neuroprotection to the eye of a human patient.

    摘要翻译： 本发明提供其中R1选自C1-C10烷氧基，OH和NR4R5; R2选自C1-C10烷基和（CH2）nOH; R3选自C1-C10烷基，杂芳基，例如C1-C10烷基。 噻吩基，呋喃基和吡啶基，苯基，单，二 - ，三取代的苯基和杂芳基; R 4和R 5独立地选自H，C 1 -C 10烷基，C 1 -C 10烷基羟基; m为0或1〜3的整数，n为1〜4的整数。这些化合物可用于降低眼内压和/或治疗青光眼或向人类患者的眼睛提供神经保护作用。

    POLYIMIDE-BASED MATERIAL, COMPOSITION AND FILM, AND MANUFACTURING METHOD THEREOF
    4.
    发明申请
    POLYIMIDE-BASED MATERIAL, COMPOSITION AND FILM, AND MANUFACTURING METHOD THEREOF 审中-公开
    基于聚酰亚胺的材料，组合物和薄膜及其制造方法

    公开(公告)号：US20100273976A1

    公开(公告)日：2010-10-28

    申请号：US12646494

    申请日：2009-12-23

    申请人： Rozhanskii IGOR ,  Takaaki Uno ,  Takashi Okada ,  Kohei Goto

    发明人： Rozhanskii IGOR ,  Takaaki Uno ,  Takashi Okada ,  Kohei Goto

    IPC分类号： C08G73/10 ,  B05D3/02 ,  C07C61/06 ,  C08G73/00

    CPC分类号： C07C61/06 ,  C08G73/105 ,  C08G73/1075 ,  C09D179/08 ,  H05K1/0346

    摘要： A polyimide-type material that exhibits an excellent heat resistance and moldability such as easiness of molding into a film configuration and low process load, and a film made from this polyimide-type material are provided. The polyimide-type material contains a polyamic acid and/or polyimide obtained by reacting (A) at least one acyl compound selected from the group consisting of 1-cis-2-cis-3-trans-4-trans-cyclopentanetetracarboxylic acid, 1-cis-2-cis-3-trans-4-trans-cyclopentanetetracarboxylic acid dianhydride, and reactive derivatives thereof, with (B) an imino-forming compound.

    摘要翻译： 提供了具有优异的耐热性和模塑性的聚酰亚胺型材料，例如成型成薄膜形状和低加工负荷的容易性，以及由该聚酰亚胺型材料制成的薄膜。 聚酰亚胺型材料含有聚酰胺酸和/或聚酰亚胺，其通过使（A）至少一种选自1-顺式-2-顺式-3-反式-4-反式 - 环戊烷四甲酸，1 - 顺式-2-顺式-3-反式-4-反式 - 环戊烷四羧酸二酐及其反应性衍生物与（B）亚氨基形成化合物反应。

    Sulfonamides
    8.
    发明授权
    Sulfonamides 有权
    磺胺类

    公开(公告)号：US07314890B2

    公开(公告)日：2008-01-01

    申请号：US11426482

    申请日：2006-06-26

    申请人： Robert M. Burk

    发明人： Robert M. Burk

    IPC分类号： A61K31/135 ,  A61K31/21 ,  C07C229/00 ,  C07C61/06

    CPC分类号： C07C311/06 ,  C07C2601/04

    摘要： The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2 is selected from the group consisting of C1-C10 alkyl and (CH2)nOH; R3 is selected from the group consisting of C1-C10 alkyl, heteroaryl, e.g. thienyl, furanyl and pyridyl, phenyl, mono, -di-, tri-substituted phenyl and heteroaryl; R4 and R5 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl hydroxyl; m is 0 or an integer from 1 to 3 and n is an integer of from 1 to 4. These compounds are useful in lowering intraocular pressure and/or treating glaucoma or providing neuroprotection to the eye of a human patient.

    摘要翻译： 本发明提供其中R 1选自C 1 -C 10烷氧基，OH和NR 4， / SUP> R＆lt; 5＆gt;; R 2选自C 1 -C 10烷基和（CH 2 N 2）N 2 > n OH; R 3选自C 1 -C 10烷基，杂芳基，例如C 1 -C 6烷基。 噻吩基，呋喃基和吡啶基，苯基，单，二 - ，三取代的苯基和杂芳基; R 4和R 5独立地选自H，C 1 -C 10烷基， C 1 -C 10烷基羟基; C 1 -C 10烷基羟基; m为0或1〜3的整数，n为1〜4的整数。这些化合物可用于降低眼内压和/或治疗青光眼或向人类患者的眼睛提供神经保护作用。