Invention Grant
US07790849B2 Enhancement of retroviral gene transduction employing polypeptides comprising the fibronectin heparin II binding domain
失效
使用包含纤连蛋白肝素II结合结构域的多肽增强逆转录病毒基因转导
- Patent Title: Enhancement of retroviral gene transduction employing polypeptides comprising the fibronectin heparin II binding domain
- Patent Title (中): 使用包含纤连蛋白肝素II结合结构域的多肽增强逆转录病毒基因转导
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Application No.: US12241581Application Date: 2008-09-30
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Publication No.: US07790849B2Publication Date: 2010-09-07
- Inventor: Kiyozo Asada , Takashi Uemori , Takashi Ueno , Nobuto Koyama , Kimikazu Hashino , Ikunoshin Kato
- Applicant: Kiyozo Asada , Takashi Uemori , Takashi Ueno , Nobuto Koyama , Kimikazu Hashino , Ikunoshin Kato
- Applicant Address: JP
- Assignee: Takara Bio Inc.
- Current Assignee: Takara Bio Inc.
- Current Assignee Address: JP
- Agency: DLA Piper LLP (US)
- Priority: JP7-294382 19951113; JP8-051847 19960308
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C07H21/04
Abstract:
An isolated polypeptide includes the amino acid sequence shown in SEQ. ID No. 13 and an isolated nucleic acid encoding the polypeptide, such as an isolated nucleic acid including the nucleic acid sequence shown in SEQ. ID No. 17. The isolated polypeptide includes two heparin binding polypeptides connected in tandem and the isolated nucleic acid encodes these. The polypeptide and nucleic acid sequences can improve retroviral vector mediated gene transfer efficiency into target cells.
Public/Granted literature
- US20090209730A1 METHOD FOR GENE TRANSFER INTO TARGET CELLS WITH RETROVIRUS Public/Granted day:2009-08-20
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