发明授权
US07799349B2 Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
有权
通过骨髓来源的细胞移植在心肌缺血组织和骨骼肌缺血组织中的治疗性血管发生
- 专利标题: Therapeutic angiogenesis by bone marrow-derived cell transplantation in myocardial ischemic tissue and skeletal muscle ischemic tissue
- 专利标题(中): 通过骨髓来源的细胞移植在心肌缺血组织和骨骼肌缺血组织中的治疗性血管发生
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申请号: US11069166申请日: 2005-02-28
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公开(公告)号: US07799349B2公开(公告)日: 2010-09-21
- 发明人: Takafumi Ueno , Toyoaki Murohara , Keith Allen Robinson , Nicolas A. F. Chronos , Sam Baldwin , Maria Palasis
- 申请人: Takafumi Ueno , Toyoaki Murohara , Keith Allen Robinson , Nicolas A. F. Chronos , Sam Baldwin , Maria Palasis
- 申请人地址: US MN Maple Grove
- 专利权人: Boston Scientific Scimed, Inc.
- 当前专利权人: Boston Scientific Scimed, Inc.
- 当前专利权人地址: US MN Maple Grove
- 代理机构: Kenyon & Kenyon LLP
- 主分类号: A61K35/28
- IPC分类号: A61K35/28 ; A61K35/26 ; C12N5/08
摘要:
This invention provides methods of forming new blood vessels in diseased or damaged tissue in a subject, methods of increasing blood flow to diseased or damaged tissue in a subject, and methods of increasing angiogenesis in diseased tissue in a subject, which methods comprise: a) isolating autologous bone marrow-mononuclear cells from the subject; and b) transplanting locally into the diseased or damaged tissue an effective amount of the autologous bone-marrow mononuclear cells, thereby forming new blood vessels in the diseased or damaged tissue. The new blood vessels may be capillaries or collateral vessels in ischemic tissue or any site of angiogenesis. Also provided are methods of treating tissue in disease or injury by local transplantation with an effective amount of the autologous bone marrow-mononuclear cells so as to induce vascularization in such diseased tissue.