发明授权
US07807681B2 Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors
有权
羟基脒和羟基胍化合物作为尿激酶抑制剂
- 专利标题： Hydroxyamidine and hydroxyguanidine compounds as urokinase inhibitors
- 专利标题（中）： 羟基脒和羟基胍化合物作为尿激酶抑制剂
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申请号： US12105975申请日： 2008-04-18
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公开(公告)号： US07807681B2公开(公告)日： 2010-10-05
- 发明人: Stefan Sperl , Markus Buergle , Wolfgang Schmalix , Katja Wosikowski , Bernd Clement
- 申请人： Stefan Sperl , Markus Buergle , Wolfgang Schmalix , Katja Wosikowski , Bernd Clement
- 申请人地址： DE Munich
- 专利权人： Wilex AG
- 当前专利权人： Wilex AG
- 当前专利权人地址： DE Munich
- 代理机构： Miles & Stockbridge P.C.
- 代理商 Gianna J. Arnold
- 优先权： DE10323898 20030526
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965
摘要：
The present invention relates to novel compounds for inhibiting the urokinase plasminogen activator (uPA), which have high bioavailability and oral administerability, and also to the use thereof as therapeutic active compounds for the treatment of urokinase- or/and urokinase receptor-associated disorders such as, for example, tumors and metastasizing. The invention relates in particular to compounds containing hydroxyamidine or hydroxyguanidine groups.
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