-
公开(公告)号：US20060142305A1
公开(公告)日：2006-06-29
申请号：US11287480
申请日：2005-11-28
IPC分类号： A61K31/495
CPC分类号： C07D295/185 , C07K5/06078 , C07K5/06191
摘要： The present invention relates to novel compounds for inhibiting the urokinase plasminogen activator (uPA), which have high bioavailability and oral administerability, and also to the use thereof as therapeutic active compounds for the treatment of urokinase- or/and urokinase receptor-associated disorders such as, for example, tumors and metastasizing. The invention relates in particular to compounds containing hydroxyamidine or hydroxyguanidine groups.
-
2.发明申请公开(公告)号：US20100068272A1
公开(公告)日：2010-03-18
申请号：US12558790
申请日：2009-09-14
IPC分类号： A61K9/28 , A61K31/495 , C07D241/04 , A61K31/18 , C07C311/00 , A61P35/00
CPC分类号： C07D295/185 , C07K5/06078 , C07K5/06191
摘要： The present invention relates to novel compounds for inhibiting the urokinase plasminogen activator (uPA), which have high bioavailability and oral administerability, and also to the use thereof as therapeutic active compounds for the treatment of urokinase- or/and urokinase receptor-associated disorders such as, for example, tumors and metastasizing. The invention relates in particular to compounds containing hydroxyamidine or hydroxyguanidine groups.
摘要翻译： 本发明涉及用于抑制尿激酶纤溶酶原激活物（uPA）的新化合物，其具有高的生物利用度和口服施用性，并且还涉及作为用于治疗尿激酶或/和尿激酶受体相关疾病的治疗活性化合物的用途， 例如，肿瘤和转移。 本发明特别涉及含有羟基脒或羟基胍基团的化合物。
-
公开(公告)号：US07608623B2
公开(公告)日：2009-10-27
申请号：US11287480
申请日：2005-11-28
IPC分类号： A61K31/4965
CPC分类号： C07D295/185 , C07K5/06078 , C07K5/06191
摘要： The present invention relates to novel compounds for inhibiting the urokinase plasminogen activator (uPA), which have high bioavailability and oral administerability, and also to the use thereof as therapeutic active compounds for the treatment of urokinase- or/and urokinase receptor-associated disorders such as, for example, tumors and metastasizing. The invention relates in particular to compounds containing hydroxyamidine or hydroxyguanidine groups.
摘要翻译： 本发明涉及用于抑制尿激酶纤溶酶原激活物（uPA）的新化合物，其具有高的生物利用度和口服施用性，并且还涉及作为用于治疗尿激酶或/和尿激酶受体相关疾病的治疗活性化合物的用途， 例如，肿瘤和转移。 本发明特别涉及含有羟基脒或羟基胍基团的化合物。
-
公开(公告)号：US07807681B2
公开(公告)日：2010-10-05
申请号：US12105975
申请日：2008-04-18
IPC分类号： A61K31/4965
CPC分类号： C07D295/185 , C07K5/06078 , C07K5/06191
摘要： The present invention relates to novel compounds for inhibiting the urokinase plasminogen activator (uPA), which have high bioavailability and oral administerability, and also to the use thereof as therapeutic active compounds for the treatment of urokinase- or/and urokinase receptor-associated disorders such as, for example, tumors and metastasizing. The invention relates in particular to compounds containing hydroxyamidine or hydroxyguanidine groups.
摘要翻译： 本发明涉及用于抑制尿激酶纤溶酶原激活物（uPA）的新化合物，其具有高的生物利用度和口服施用性，并且还涉及作为用于治疗尿激酶或/和尿激酶受体相关疾病的治疗活性化合物的用途， 例如，肿瘤和转移。 本发明特别涉及含有羟基脒或羟基胍基团的化合物。
-
公开(公告)号：US20080261998A1
公开(公告)日：2008-10-23
申请号：US12105975
申请日：2008-04-18
IPC分类号： A61K31/495 , A61P35/00 , A61P35/04
CPC分类号： C07D295/185 , C07K5/06078 , C07K5/06191
摘要： The present invention relates to novel compounds for inhibiting the urokinase plasminogen activator (uPA), which have high bioavailability and oral administerability, and also to the use thereof as therapeutic active compounds for the treatment of urokinase- or/and urokinase receptor-associated disorders such as, for example, tumors and metastasizing. The invention relates in particular to compounds containing hydroxyamidine or hydroxyguanidine groups.
摘要翻译： 本发明涉及用于抑制尿激酶纤溶酶原激活物（uPA）的新化合物，其具有高的生物利用度和口服施用性，并且还涉及作为用于治疗尿激酶或/和尿激酶受体相关疾病的治疗活性化合物的用途， 例如，肿瘤和转移。 本发明特别涉及含有羟基脒或羟基胍基团的化合物。
-
公开(公告)号：US20060105943A1
公开(公告)日：2006-05-18
申请号：US11321534
申请日：2005-12-30
IPC分类号： A61K38/12
CPC分类号： C12N9/6462 , A61K38/00 , C07K7/64 , C12Y304/21073
摘要： The present invention relates to cyclic peptides as inhibitors of urokinase binding to the urokinase receptor. Said cyclic peptides are suitable as pharmaceutical active substances for disorders mediated by urokinase and its receptor.
-
公开(公告)号：US07045504B2
公开(公告)日：2006-05-16
申请号：US11018311
申请日：2004-12-22
IPC分类号： A61K38/00
CPC分类号： C12N9/6462 , A61K38/00 , C07K7/64 , C12Y304/21073
摘要： The present invention relates to cyclic peptides as inhibitors of urokinase binding to the urokinase receptor. Said cyclic peptides are suitable as pharmaceutical active substances for disorders mediated by urokinase and its receptor.
摘要翻译： 本发明涉及作为尿激酶结合尿激酶受体的抑制剂的环肽。 所述环肽适合作为尿激酶及其受体介导的病症的药物活性物质。
-
公开(公告)号：US07314863B2
公开(公告)日：2008-01-01
申请号：US11321534
申请日：2005-12-30
IPC分类号： A61K38/00
CPC分类号： C12N9/6462 , A61K38/00 , C07K7/64 , C12Y304/21073
摘要： The present invention relates to cyclic peptides as inhibitors of urokinase binding to the urokinase receptor. Said cyclic peptides are suitable as pharmaceutical active substances for disorders mediated by urokinase and its receptor.
摘要翻译： 本发明涉及作为尿激酶结合尿激酶受体的抑制剂的环肽。 所述环肽适合作为尿激酶及其受体介导的病症的药物活性物质。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.027 秒)
