发明授权
US07811577B2 Covalently stabilized chimeric coiled-coil HIV gp41 N-peptides with improved antiviral activity
有权
具有改善的抗病毒活性的共价稳定的嵌合卷曲螺旋HIV gp41 N-肽
- 专利标题: Covalently stabilized chimeric coiled-coil HIV gp41 N-peptides with improved antiviral activity
- 专利标题(中): 具有改善的抗病毒活性的共价稳定的嵌合卷曲螺旋HIV gp41 N-肽
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申请号: US11628483申请日: 2005-05-27
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公开(公告)号: US07811577B2公开(公告)日: 2010-10-12
- 发明人: Elisabetta Bianchi , Antonello Pessi , Romas Geleziunas , David Bramhill
- 申请人: Elisabetta Bianchi , Antonello Pessi , Romas Geleziunas , David Bramhill
- 申请人地址: US NJ Rahway IT Rome
- 专利权人: Merck Sharp & Dohme Corp.,Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.A.
- 当前专利权人: Merck Sharp & Dohme Corp.,Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.A.
- 当前专利权人地址: US NJ Rahway IT Rome
- 代理商 Henry P. Wu; Sheldon O. Heber
- 国际申请: PCT/US2005/018808 WO 20050527
- 国际公布: WO2005/118886 WO 20051215
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; A61K39/21
摘要:
Methods of covalently-stabilizing alpha-helical, chimeric peptides constrained within a homotrimeric or heterotrimeric coiled-coil structure are disclosed. The coiled-coil structures made by the methods disclosed within this specification mimic all or a portion of the internal, trimeric coiled-coil motif contained within the fusogenic conformation of an enveloped virus membrane-fusion protein, particularly the internal coiled-coil domain of the HIV gp41 ectodomain. The HIV-derived, chimeric peptides disclosed comprise a non-HIV, soluble, trimeric form of a coiled-coil fused in helical phase to all or a portion of the N-helix of HIV gp41 and are covalently-stabilized in a homotrimeric or heterotrimeric coiled-coil structure through the formation of disulfide or chemoselective bonds between said peptides. The covalently-stabilized, HIV-derived, homotrimeric or heterotrimeric coiled-coil structures made by the methods disclosed herein represent a close mimetic of a HIV gp41 fusion intermediate and are potent inhibitors of HIV infectivity. These HIV-derived chimeric peptides may provide for therapeutic treatment against HIV infection by inhibiting the virus-host cell membrane fusion process.
公开/授权文献
- US20070224212A1 Stable Peptide Mimetic of Hiv Gp41 Fusion Intermediate 公开/授权日:2007-09-27