发明授权
US07812145B2 Short isoform of annexin A10 at chromosome 4q, termed annexin 10s (ANXA 10s) and methods of use
有权
4q染色体上膜联蛋白A10的短异型，称为膜联蛋白10（ANXA 10s）和使用方法
- 专利标题： Short isoform of annexin A10 at chromosome 4q, termed annexin 10s (ANXA 10s) and methods of use
- 专利标题（中）： 4q染色体上膜联蛋白A10的短异型，称为膜联蛋白10（ANXA 10s）和使用方法
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申请号： US12346241申请日： 2008-12-30
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公开(公告)号： US07812145B2公开(公告)日： 2010-10-12
- 发明人: Hey-Chi Hsu , David C. P. Chen
- 申请人： Hey-Chi Hsu , David C. P. Chen
- 申请人地址： TW Kaohsiung
- 专利权人： Asia Hepato Gene Company
- 当前专利权人： Asia Hepato Gene Company
- 当前专利权人地址： TW Kaohsiung
- 代理机构： Occhiuti Rohlicek & Tsao LLP
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/00 ; C12N5/10
摘要：
The present invention includes compositions including a novel short isoform of Annexin A10, termed Annexin 10s (ANXA10s) and methods of use. The compositions include nucleic acid molecules encoding ANXA10s, ANXA10s polypeptides, ANXA10s amino acid sequences and derivatives or modifications thereof. Included in these methods are the interrelation of the aberrant expressions of AFP, OPN, and the novel liver specific short isoform, ANXA10s, at human Chromosome 4q in the progression of hepatocellular carcinoma (HCC). The aberrant expressions of AFP, OPN and ANXA10s are shown to act cooperatively toward advanced disease, which could be useful for diagnostic, molecular staging or treatment of a patient having HCC or at risk of developing HCC.
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