发明授权
- 专利标题： Packaging cells for recombinant adenovirus
- 专利标题（中）： 用于重组腺病毒的包装细胞
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申请号： US11384850申请日： 2006-03-20
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公开(公告)号： US07816104B2公开(公告)日： 2010-10-19
- 发明人: Ronald Vogels , Menzo Jans Emco Havenga , David Adrianus Theodorus Maria Zuijdgeest
- 申请人： Ronald Vogels , Menzo Jans Emco Havenga , David Adrianus Theodorus Maria Zuijdgeest
- 申请人地址： NL Leiden
- 专利权人： Crucell Holland B.V.
- 当前专利权人： Crucell Holland B.V.
- 当前专利权人地址： NL Leiden
- 代理机构： TraskBritt
- 优先权： WOPCT/EP03/50679 20031002
- 主分类号： C12P19/34
- IPC分类号： C12P19/34 ; C12N7/00 ; A61K48/00
摘要：
In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. The invention provides means and methods reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided.
公开/授权文献
- US20060183232A1 Packaging cells for recombinant adenovirus 公开/授权日：2006-08-17
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