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公开(公告)号：US07816104B2
公开(公告)日：2010-10-19
申请号：US11384850
申请日：2006-03-20
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2830/38
摘要： In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. The invention provides means and methods reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided.
摘要翻译： 在重组腺病毒载体和包装细胞基因组之间不存在实质的序列重叠的情况下，可以以低频形成辅助依赖性的含有E1的颗粒（HDEP）。 本发明提供减少或防止HDEP产生的方法和方法。 为此，提供了新颖的包装电池及其制造方法。
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公开(公告)号：US20080206837A1
公开(公告)日：2008-08-28
申请号：US11899572
申请日：2007-09-05
IPC分类号： C12N7/01
CPC分类号： C12N15/86 , A61K2039/5256 , C12N2710/10343 , C12N2840/20 , C12N2840/44
摘要： Provided are methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by retaining at least a part of the E1B-55K region in the recombinant adenoviral vector or by regulating pIX with a heterologous promoter. The invention further relates to methods and means for the production of such adenoviruses on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenovirus and wherein the E4-orf6 gene product is compatible with one or more products of the E1 gene products in the complementing cell, such that the adenoviral vector can be efficiently produced by the complementing cell.
摘要翻译： 提供了通过在腺病毒包装细胞中过表达pIX，通过在重组腺病毒载体中保留至少一部分E1B-55K区域或通过调节pIX来提高重组腺病毒的稳定性和/或包装能力的方法和手段 与异源启动子。 本发明还涉及在补体细胞系上产生这种腺病毒的方法和装置，其中编码核酸的早期区域4开放阅读框6（E4-orf6）存在于腺病毒中，其中E4-orf6基因产物是 与补体细胞中E1基因产物的一种或多种产物相容，使得腺病毒载体可以通过补体细胞有效产生。
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公开(公告)号：US08114637B2
公开(公告)日：2012-02-14
申请号：US12804179
申请日：2010-07-14
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2830/38
摘要： In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. Provided are means and methods for reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided.
摘要翻译： 在重组腺病毒载体和包装细胞基因组之间不存在实质的序列重叠的情况下，可以以低频形成辅助依赖性的含有E1的颗粒（HDEP）。 提供减少或防止HDEP产生的手段和方法。 为此，提供了新颖的包装电池及其制造方法。
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公开(公告)号：US08052967B2
公开(公告)日：2011-11-08
申请号：US11899572
申请日：2007-09-05
CPC分类号： C12N15/86 , A61K2039/5256 , C12N2710/10343 , C12N2840/20 , C12N2840/44
摘要： Provided are methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by retaining at least a part of the E1B-55K region in the recombinant adenoviral vector or by regulating pIX with a heterologous promoter. The invention further relates to methods and means for the production of such adenoviruses on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenovirus and wherein the E4-orf6 gene product is compatible with one or more products of the E1 gene products in the complementing cell, such that the adenoviral vector can be efficiently produced by the complementing cell.
摘要翻译： 提供了通过在腺病毒包装细胞中过表达pIX，通过在重组腺病毒载体中保留至少一部分E1B-55K区域或通过调节pIX来提高重组腺病毒的稳定性和/或包装能力的方法和手段 与异源启动子。 本发明还涉及在补体细胞系上产生这种腺病毒的方法和装置，其中编码核酸的早期区域4开放阅读框6（E4-orf6）存在于腺病毒中，其中E4-orf6基因产物是 与补体细胞中E1基因产物的一种或多种产物相容，使得腺病毒载体可以通过补体细胞有效产生。
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公开(公告)号：US20100311172A1
公开(公告)日：2010-12-09
申请号：US12804179
申请日：2010-07-14
IPC分类号： C12N15/87
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2830/38
摘要： In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. Provided are means and methods for reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided.
摘要翻译： 在重组腺病毒载体和包装细胞基因组之间不存在实质的序列重叠的情况下，可以以低频形成辅助依赖性的含有E1的颗粒（HDEP）。 提供减少或防止HDEP产生的手段和方法。 为此，提供了新颖的包装电池及其制造方法。
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公开(公告)号：US07285265B2
公开(公告)日：2007-10-23
申请号：US10512602
申请日：2003-04-24
CPC分类号： C12N15/86 , A61K2039/5256 , C12N2710/10343 , C12N2840/20 , C12N2840/44
摘要： The present invention provides methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by retaining at least a part of the E1B 55K region in the recombinant adenoviral vector or by regulating pIX with a heterologous promoter. The invention further relates to methods and means for the production of such adenoviruses on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenovirus and wherein the E4-orf6 gene product is compatible with one or more products of the E1 gene products in the complementing cell, such that the adenoviral vector can be efficiently produced by the complementing cell.
摘要翻译： 本发明提供了通过在腺病毒包装细胞中过表达pIX，通过在重组腺病毒载体中保留至少一部分E1B55K区域或通过调节重组腺病毒载体中的E1B 55K区域的至少一部分来提高重组腺病毒的稳定性和/或包装能力的方法和手段 pIX与异源启动子。 本发明还涉及在补体细胞系上产生这种腺病毒的方法和装置，其中编码核酸的早期区域4开放阅读框6（E4-orf6）存在于腺病毒中，其中E4-orf6基因产物是 与补体细胞中E1基因产物的一种或多种产物相容，使得腺病毒载体可以通过补体细胞有效产生。
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7.发明授权Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses 有权能够中和系统发育组1和系统发育组2和乙型流感病毒的甲型流感病毒的人结合分子公开(公告)号：US08961978B2
公开(公告)日：2015-02-24
申请号：US14126404
申请日：2012-07-12
申请人： Theodorus Hendrikus Jacobus Kwaks , David Adrianus Theodorus Maria Zuijdgeest , Ronald Vogels , Robert Heinz Edward Friesen
发明人： Theodorus Hendrikus Jacobus Kwaks , David Adrianus Theodorus Maria Zuijdgeest , Ronald Vogels , Robert Heinz Edward Friesen
CPC分类号： C07K16/1018 , A61K39/42 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/70 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/11
摘要： The present disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. The disclosure provides nucleic acid molecules encoding the binding molecules, their sequences and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses.
摘要翻译： 本公开涉及结合分子系统发生的第1组和第2组甲型流感病毒以及乙型流感病毒血凝素的表位的结合分子，例如人单克隆抗体，并具有广泛的中和活性 针对这种流感病毒。 本公开提供编码结合分子的核酸分子，其序列和包含结合分子的组合物。 结合分子可用于诊断，预防和/或治疗系统发育组1和2的甲型流感病毒以及乙型流感病毒。
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8.发明申请HUMAN BINDING MOLECULES CAPABLE OF NEUTRALIZING INFLUENZA A VIRUSES OF PHYLOGENETIC GROUP 1 AND PHYLOGENETIC GROUP 2 AND INFLUENZA B VIRUSES 有权人类结合分子可以使中性粒细胞病毒1型和生物群2和流感病毒B病毒的病毒中毒公开(公告)号：US20140120113A1
公开(公告)日：2014-05-01
申请号：US14126404
申请日：2012-07-12
申请人： Theodorus Hendrikus Jacobus Kwaks , David Adrianus Theodorus Maria Zuijdgeest , Ronald Vogels , Robert Heinz Edward Friesen
发明人： Theodorus Hendrikus Jacobus Kwaks , David Adrianus Theodorus Maria Zuijdgeest , Ronald Vogels , Robert Heinz Edward Friesen
IPC分类号： C07K16/10
CPC分类号： C07K16/1018 , A61K39/42 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/70 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/11
摘要： The present disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. The disclosure provides nucleic acid molecules encoding the binding molecules, their sequences and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses.
摘要翻译： 本公开涉及结合分子系统发生的第1组和第2组甲型流感病毒以及乙型流感病毒血凝素的表位的结合分子，例如人单克隆抗体，并具有广泛的中和活性 针对这种流感病毒。 本公开提供编码结合分子的核酸分子，其序列和包含结合分子的组合物。 结合分子可用于诊断，预防和/或治疗系统发育组1和2的甲型流感病毒以及乙型流感病毒。
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