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发明授权
US07816351B2 5,6-dimethylthieno[2,3-di] pyrimidine derivatives, the preparation method thereof and the pharmaceutical composition comprising the same for anti-virus 有权
5,6-二甲基噻吩并[2,3-d]嘧啶衍生物，其制备方法和包含其的药物组合物用于抗病毒

5,6-dimethylthieno[2,3-di] pyrimidine derivatives, the preparation method thereof and the pharmaceutical composition comprising the same for anti-virus
摘要：
Disclosed herein are 5,β-dimethylthieno[2,3-d]pyrimidine derivatives useful as antiviral agents. More particularly, disclosed are 5,β-dimethylthieno[2,3-djpyrimidine derivatives represented by Formula 1, having an excellent inhibitory effect on the proliferation of hepatitis C virus (HCV), pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the prevention and treatment of hepatitis C virus (HCV), containing, as active ingredients, these compounds. The 5,6-dimethylthieno[2,3-d]pyrimidine derivatives represented by Formula 1 have an excellent effect of inhibiting the proliferation of hepatitis C virus and also have low toxicity. Thus, these compounds are available as agents for the prevention and treatment of hepatitis C.
摘要（中）：

本文公开了可用作抗病毒剂的5'，bgr-二甲基噻吩并[2,3-d]嘧啶衍生物。 更具体地，公开了具有对丙型肝炎病毒（HCV）增殖具有优异抑制作用的式1表示的5α-二甲基噻吩并[2,3-d]嘧啶衍生物，其药学上可接受的盐，其制备方法和 用于预防和治疗丙型肝炎病毒（HCV）的药物组合物，其含有这些化合物作为活性成分。 由式1表示的5,6-二甲基噻吩并[2,3-d]嘧啶衍生物具有抑制丙型肝炎病毒增殖并且毒性低的优异效果。 因此，这些化合物可用作预防和治疗丙型肝炎的药剂。

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