公开(公告)号：US07816351B2

公开(公告)日：2010-10-19

申请号：US12067246

申请日：2005-09-23

申请人： Cheol Kyu Han ,  Jeonghyeok Yoon ,  Nam-Doo Kim ,  Jin-ah Kim

发明人： Cheol Kyu Han ,  Jeonghyeok Yoon ,  Nam-Doo Kim ,  Jin-ah Kim

IPC分类号： A61K31/5377 ,  C07D413/14

CPC分类号： C07D495/04

摘要： Disclosed herein are 5,β-dimethylthieno[2,3-d]pyrimidine derivatives useful as antiviral agents. More particularly, disclosed are 5,β-dimethylthieno[2,3-djpyrimidine derivatives represented by Formula 1, having an excellent inhibitory effect on the proliferation of hepatitis C virus (HCV), pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the prevention and treatment of hepatitis C virus (HCV), containing, as active ingredients, these compounds. The 5,6-dimethylthieno[2,3-d]pyrimidine derivatives represented by Formula 1 have an excellent effect of inhibiting the proliferation of hepatitis C virus and also have low toxicity. Thus, these compounds are available as agents for the prevention and treatment of hepatitis C.

摘要翻译： 本文公开了可用作抗病毒剂的5'，bgr-二甲基噻吩并[2,3-d]嘧啶衍生物。 更具体地，公开了具有对丙型肝炎病毒（HCV）增殖具有优异抑制作用的式1表示的5α-二甲基噻吩并[2,3-d]嘧啶衍生物，其药学上可接受的盐，其制备方法和 用于预防和治疗丙型肝炎病毒（HCV）的药物组合物，其含有这些化合物作为活性成分。 由式1表示的5,6-二甲基噻吩并[2,3-d]嘧啶衍生物具有抑制丙型肝炎病毒增殖并且毒性低的优异效果。 因此，这些化合物可用作预防和治疗丙型肝炎的药剂。

公开(公告)号：US20080234482A1

公开(公告)日：2008-09-25

申请号：US12067246

申请日：2005-09-23

申请人： Cheol Kyu Han ,  Jeonghyeok Yoon ,  Nam-Doo Kim ,  Jin-ah Kim

发明人： Cheol Kyu Han ,  Jeonghyeok Yoon ,  Nam-Doo Kim ,  Jin-ah Kim

IPC分类号： C07D495/04

CPC分类号： C07D495/04

摘要： Disclosed herein are 5,β-dimethylthieno[2,3-d]pyrimidine derivatives useful as antiviral agents. More particularly, disclosed are 5,β-dimethylthieno[2,3-djpyrimidine derivatives represented by Formula 1, having an excellent inhibitory effect on the proliferation of hepatitis C virus (HCV), pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the prevention and treatment of hepatitis C virus (HCV), containing, as active ingredients, these compounds. The 5,6-dimethylthieno[2,3-d]pyrimidine derivatives represented by Formula 1 have an excellent effect of inhibiting the proliferation of hepatitis C virus and also have low toxicity. Thus, these compounds are available as agents for the prevention and treatment of hepatitis C.

摘要翻译： 本文公开了可用作抗病毒剂的5β-二甲基噻吩并[2,3-d]嘧啶衍生物。 更具体地，公开了5种由式1表示的β-二甲基噻吩并[2,3-d]嘧啶衍生物，其对丙型肝炎病毒（HCV）的增殖具有优异的抑制作用，其药学上可接受的盐，其制备方法和 用于预防和治疗丙型肝炎病毒（HCV）的药物组合物，其含有作为活性成分的这些化合物。 由式1表示的5,6-二甲基噻吩并[2,3-d]嘧啶衍生物具有抑制丙型肝炎病毒增殖并且毒性低的优异效果。 因此，这些化合物可用作预防和治疗丙型肝炎的药剂。